Fundamentals of Neurogastroenterology: Basic Science

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2016 May 5

PMID 27144618

Citations 46

Authors

Stephen Vanner

Beverley Greenwood-Van Meerveld

Gary Mawe

Terez Shea-Donohue

Elena F Verdu

Jackie Wood

David Grundy

Affiliations

Soon will be listed here.

Abstract

This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled ROME IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs and new areas for future research into their pathophysiology.

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