Effectiveness of 3% Hypertonic Saline Nebulization in Acute Bronchiolitis Among Indian Children: A Quasi-experimental Study

Overview

Journal Perspect Clin Res

Specialty General Medicine

Date 2016 May 4

PMID 27141475

Citations 7

Authors

Harsh V Gupta

Vivek V Gupta

Gurmeet Kaur

Amitoz S Baidwan

Pardeep P George

Jay C Shah

Kushal Shinde

Ruku Malik

Neha Chitkara

Krushnan V Bajaj

Affiliations

Soon will be listed here.

Abstract

Objective: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis.

Materials And Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis.

Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3(rd) day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000). The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001).

Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators) is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner.

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