Peripheral Trafficking of Bone-marrow-derived Stem Cells in Patients with Different Types of Gastric Neoplasms

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2016 May 4

PMID 27141380

Citations 10

Authors

Wojciech Blogowski

Ewa Zuba-Surma

Daria Salata

Marta Budkowska

Barbara Dolegowska

Teresa Starzynska

Affiliations

Soon will be listed here.

Abstract

Recently, there has been a growing interest in the importance of stem cells (SCs) in the development/progression of gastric neoplasms. In this study, we performed a comprehensive analysis of different populations of bone-marrow-derived stem cells (BMSCs) in patients with various types of gastric malignancies, including gastric cancer, gastrointestinal stromal tumors (GISTs), neuroendocrine neoplasms (NENs), and lymphomas. We found significantly lower numbers of circulating Lin-/CD45 +/ CD133 + hematopoietic stem/progenitor cells (HSPCs), and intensified peripheral trafficking of both Lin-/CD45-/CXCR4+/CD34+/CD133+ very small embryonic/epiblast-like stem cells (VSELs) and CD105 + /STRO-1 +/ CD45- mesenchymal SCs (MSCs) in patients with gastric cancer, but not in those with other types of gastric neoplasms. No significant differences in the absolute numbers of circulating CD34 +/ KDR +/ CD31 +/ CD45- endothelial progenitor cells (EPCs) were observed between the groups. This abnormal balance in the peripheral trafficking of BMSCs in patients with gastric cancer was neither associated with clinical stage of the disease nor with systemic levels of stromal-derived factor-1 (SDF-1), as these were comparable to the values observed in control individuals. Interestingly, the absolute numbers of circulating BMSCs correlated with the concentrations of complement cascade-derived anaphylatoxins/molecules (mainly C5b-9/membrane attack complex-MAC) and sphingosine-1-phosphate (S1P). In summary, our translational study revealed that abnormal peripheral trafficking of BMSCs occurs in patients with gastric cancer, but not in those with other types of gastric neoplasms. Further, our findings indicate that highlighted complement cascade-derived molecules and S1P, but not SDF-1, are significant players associated with this phenomenon.

Citing Articles

SOX2 contributes to invasion and poor prognosis of gastric cancer: A meta-analysis.

Tang K, Liu J, Liu B, Meng C, Liao J Medicine (Baltimore). 2022; 101(36):e30559.

PMID: 36086709 PMC: 10980484. DOI: 10.1097/MD.0000000000030559.

Mesenchymal Stem Cells in Gastric Cancer: Vicious but Hopeful.

Li Y, Zhong X, Zhang Y, Lu X Front Oncol. 2021; 11:617677.

PMID: 34046337 PMC: 8144497. DOI: 10.3389/fonc.2021.617677.

CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC.

Wang W, Zhang Y, Liu W, Zhang X, Xiao H, Zhao M Theranostics. 2020; 10(25):11549-11561.

PMID: 33052232 PMC: 7545993. DOI: 10.7150/thno.44251.

Clinical significance of various growth factors in patients with different gastric neoplasms.

Kedzierska L, Madej-Michniewicz A, Marczuk N, Dolegowska B, Starzynska T, Blogowski W Am J Transl Res. 2020; 12(1):118-129.

PMID: 32051741 PMC: 7013217.

Mobilization of Stem and Progenitor Cells in Septic Shock Patients.

Skirecki T, Mikaszewska-Sokolewicz M, Godlewska M, Dolegowska B, Czubak J, Hoser G Sci Rep. 2019; 9(1):3289.

PMID: 30824730 PMC: 6397313. DOI: 10.1038/s41598-019-39772-4.

References

Marlicz W, Zuba-Surma E, Kucia M, Blogowski W, Starzynska T, Ratajczak M . Various types of stem cells, including a population of very small embryonic-like stem cells, are mobilized into peripheral blood in patients with Crohn's disease. Inflamm Bowel Dis. 2012; 18(9):1711-22. DOI: 10.1002/ibd.22875. View

Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A . S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood. 2012; 119(11):2478-88. PMC: 4017293. DOI: 10.1182/blood-2011-06-358614. View

Starzynska T, Dabkowski K, Blogowski W, Zuba-Surma E, Budkowska M, Salata D . An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. J Cell Mol Med. 2013; 17(6):792-9. PMC: 3823183. DOI: 10.1111/jcmm.12065. View

Ceradini D, Kulkarni A, Callaghan M, Tepper O, Bastidas N, Kleinman M . Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 2004; 10(8):858-64. DOI: 10.1038/nm1075. View

Chen T, Yang K, Yu J, Meng W, Yuan D, Bi F . Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients. Cell Res. 2011; 22(1):248-58. PMC: 3351913. DOI: 10.1038/cr.2011.109. View

Blogowski W, Dolegowska B, Budkowska M, Salata D, Domanski L, Starzynska T . Perioperative release of pro-regenerative biochemical signals from human renal allografts subjected to ischemia-reperfusion injury. Innate Immun. 2013; 20(2):126-32. DOI: 10.1177/1753425913482018. View

Wang X, Zhang H, He H, Shen Z, Tang Z, Xu J . Prognostic value of stromal cell-derived factor 1 expression in patients with gastric cancer after surgical resection. Cancer Sci. 2014; 105(11):1447-56. PMC: 4462371. DOI: 10.1111/cas.12531. View

Blogowski W, Serwin K, Budkowska M, Salata D, Dolegowska B, Lokaj M . Clinical analysis of systemic and adipose tissue levels of selected hormones/adipokines and stromal-derived factor-1. J Biol Regul Homeost Agents. 2012; 26(4):607-15. View

Rocco A, Liguori E, Pirozzi G, Tirino V, Compare D, Franco R . CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors. J Cell Physiol. 2011; 227(6):2686-93. DOI: 10.1002/jcp.23013. View

10.

Zhao B, Wang Z, Mao W, Ma H, Han J, Zhao B . CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. World J Gastroenterol. 2011; 17(19):2389-96. PMC: 3103791. DOI: 10.3748/wjg.v17.i19.2389. View

11.

Takaishi S, Okumura T, Wang T . Gastric cancer stem cells. J Clin Oncol. 2008; 26(17):2876-82. PMC: 2743304. DOI: 10.1200/JCO.2007.15.2603. View

12.

Orr F, Delikatny E, Mokashi S, Krepart G, Stiver H . Detection of a complement-derived chemotactic factor for tumor cells in human inflammatory and neoplastic effusions. Am J Pathol. 1983; 110(1):41-7. PMC: 1916132. View

13.

Ratajczak M, Kim C . Bioactive Sphingolipids and Complement Cascade as New Emerging Regulators of Stem Cell Mobilization and Homing. J Stem Cell Res Ther. 2014; 1(2). PMC: 3874276. DOI: 10.4172/2157-7633.1000e102. View

14.

Stoicov C, Li H, Liu J, Houghton J . Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation. Dig Dis Sci. 2013; 58(9):2466-77. PMC: 3766519. DOI: 10.1007/s10620-013-2782-y. View

15.

Kim H, Song K, Kim H, Chung J, Lee K, Lee Y . Circulating numbers of endothelial progenitor cells in patients with gastric and breast cancer. Cancer Lett. 2003; 198(1):83-8. DOI: 10.1016/s0304-3835(03)00268-4. View

16.

Pantel K, Alix-Panabieres C . Bone marrow as a reservoir for disseminated tumor cells: a special source for liquid biopsy in cancer patients. Bonekey Rep. 2014; 3:584. PMC: 4238319. DOI: 10.1038/bonekey.2014.79. View

17.

Stojnev S, Krstic M, Ristic-Petrovic A, Stefanovic V, Hattori T . Gastric cancer stem cells: therapeutic targets. Gastric Cancer. 2013; 17(1):13-25. DOI: 10.1007/s10120-013-0254-x. View

18.

Li K, Dan Z, Nie Y . Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment. World J Gastroenterol. 2014; 20(18):5420-6. PMC: 4017057. DOI: 10.3748/wjg.v20.i18.5420. View

19.

Blogowski W, Dolegowska B, Salata D, Budkowska M, Domanski L, Starzynska T . Clinical analysis of perioperative complement activity during ischemia/reperfusion injury following renal transplantation. Clin J Am Soc Nephrol. 2012; 7(11):1843-51. PMC: 3488944. DOI: 10.2215/CJN.02200312. View

20.

Asadi M, Mowla S, Fathi F, Aleyasin A, Asadzadeh J, Atlasi Y . OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor. Int J Cancer. 2010; 128(11):2645-52. DOI: 10.1002/ijc.25643. View