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Lack of Evidence for GDF11 As a Rejuvenator of Aged Skeletal Muscle Satellite Cells

Overview
Journal Aging Cell
Specialties Cell Biology
Geriatrics
Date 2016 May 4
PMID 27139744
Citations 46
Authors
Aaron C Hinken
Janine M Powers
Guizhen Luo
Jason A Holt
Andrew N Billin
Alan J Russell
Affiliations
Soon will be listed here.
Abstract

Recent high-profile studies report GDF11 to be a key circulating 'anti-aging' factor. However, a screen of extracellular proteins attempting to identify factors with 'anti-aging' phenotypes in aged murine skeletal muscle satellite cells did not identify GDF11 activity. We have been unable to confirm the reported activity of GDF11, similar to other laboratories offering conflicting data and describe our attempts to do so in this short take.

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