Respiratory Motor Training and Neuromuscular Plasticity in Patients with Chronic Obstructive Pulmonary Disease: A Pilot Study

Overview

Journal Respir Physiol Neurobiol

Specialty Pulmonary Medicine

Date 2016 May 4

PMID 27137413

Citations 7

Authors

Alexander V Ovechkin

Dimitry G Sayenko

Elena N Ovechkina

Sevda C Aslan

Teresa Pitts

Rodney J Folz

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to examine the feasibility of a full-scale investigation of the neurophysiological mechanisms of COPD-induced respiratory neuromuscular control deficits. Characterization of respiratory single- and multi-muscle activation patterns using surface electromyography (sEMG) were assessed along with functional measures at baseline and following 21±2 (mean±SD) sessions of respiratory motor training (RMT) performed during a one-month period in four patients with GOLD stage II or III COPD. Pre-training, the individuals with COPD showed significantly increased (p<0.05) overall respiratory muscle activity and disorganized multi-muscle activation patterns in association with lowered spirometrical measures and decreased fast- and slow-twitch fiber activity as compared to healthy controls (N=4). Following RMT, functional and respiratory sEMG activation outcomes during quite breathing and forced expiratory efforts were improved suggesting that functional improvements, induced by task-specific RMT, are evidence respiratory neuromuscular networks re-organization.

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References

Mannino D, Martinez F . Lifetime risk of COPD: what will the future bring?. Lancet. 2011; 378(9795):964-5. DOI: 10.1016/S0140-6736(11)61188-4. View

Hart N, Laffont I, de la Sota A, Lejaille M, Macadou G, Polkey M . Respiratory effects of combined truncal and abdominal support in patients with spinal cord injury. Arch Phys Med Rehabil. 2005; 86(7):1447-51. DOI: 10.1016/j.apmr.2004.12.025. View

Aminoff M, Sears T . Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones. J Physiol. 1971; 215(2):557-75. PMC: 1331899. DOI: 10.1113/jphysiol.1971.sp009485. View

McKenzie D, Butler J, Gandevia S . Respiratory muscle function and activation in chronic obstructive pulmonary disease. J Appl Physiol (1985). 2009; 107(2):621-9. DOI: 10.1152/japplphysiol.00163.2009. View

Gandevia S, Leeper J, McKenzie D, De Troyer A . Discharge frequencies of parasternal intercostal and scalene motor units during breathing in normal and COPD subjects. Am J Respir Crit Care Med. 1996; 153(2):622-8. DOI: 10.1164/ajrccm.153.2.8564108. View

Blasio F, Polverino M . Current best practice in pulmonary rehabilitation for chronic obstructive pulmonary disease. Ther Adv Respir Dis. 2012; 6(4):221-37. DOI: 10.1177/1753465812444712. View

. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002; 166(4):518-624. DOI: 10.1164/rccm.166.4.518. View

Mantilla C, Sieck G . Neuromotor control in chronic obstructive pulmonary disease. J Appl Physiol (1985). 2013; 114(9):1246-52. DOI: 10.1152/japplphysiol.01212.2012. View

Gea J, Agusti A, Roca J . Pathophysiology of muscle dysfunction in COPD. J Appl Physiol (1985). 2013; 114(9):1222-34. DOI: 10.1152/japplphysiol.00981.2012. View

10.

Smyth R, Chapman K, Rebuck A . Maximal inspiratory and expiratory pressures in adolescents. Normal values. Chest. 1984; 86(4):568-72. DOI: 10.1378/chest.86.4.568. View

11.

Orozco-Levi M . Structure and function of the respiratory muscles in patients with COPD: impairment or adaptation?. Eur Respir J Suppl. 2003; 46:41s-51s. DOI: 10.1183/09031936.03.00004607. View

12.

Lefton-Greif M, McGrath-Morrow S . Deglutition and respiration: development, coordination, and practical implications. Semin Speech Lang. 2007; 28(3):166-79. DOI: 10.1055/s-2007-984723. View

13.

Mueller G, Perret C, Spengler C . Optimal intensity for respiratory muscle endurance training in patients with spinal cord injury. J Rehabil Med. 2006; 38(6):381-6. DOI: 10.1080/16501970600780369. View

14.

Vestbo J, Hurd S, Agusti A, Jones P, Vogelmeier C, Anzueto A . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2012; 187(4):347-65. DOI: 10.1164/rccm.201204-0596PP. View

15.

Decima E, VON EULER C, Thoden U . Intercostal-to-phrenic reflexes in the spinal cat. Acta Physiol Scand. 1969; 75(4):568-79. View

16.

Aslan S, Chopra M, McKay W, Folz R, Ovechkin A . Evaluation of respiratory muscle activation using respiratory motor control assessment (RMCA) in individuals with chronic spinal cord injury. J Vis Exp. 2013; (77). PMC: 3740445. DOI: 10.3791/50178. View

17.

Kim H, Mofarrahi M, Hussain S . Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2009; 3(4):637-58. PMC: 2650609. DOI: 10.2147/copd.s4480. View

18.

Griffiths L, McConnell A . The influence of inspiratory and expiratory muscle training upon rowing performance. Eur J Appl Physiol. 2006; 99(5):457-66. DOI: 10.1007/s00421-006-0367-6. View

19.

Bartuzi P, Roman-Liu D, Tokarski T . A study of the influence of muscle type and muscle force level on individual frequency bands of the EMG power spectrum. Int J Occup Saf Ergon. 2007; 13(3):241-54. DOI: 10.1080/10803548.2007.11076725. View

20.

De Troyer A, Estenne M, Heilporn A . Mechanism of active expiration in tetraplegic subjects. N Engl J Med. 1986; 314(12):740-4. DOI: 10.1056/NEJM198603203141203. View