In Vivo Imaging of Dendritic Pruning in Dentate Granule Cells

Overview

Journal Nat Neurosci

Date 2016 May 3

PMID 27135217

Citations 49

Authors

J Tiago Goncalves

Cooper W Bloyd

Matthew Shtrahman

Stephen T Johnston

Simon T Schafer

Sarah L Parylak

Thanh Tran

Tina Chang

Fred H Gage

Affiliations

Soon will be listed here.

Abstract

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

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