What Goes Around Comes Around: Novel Pharmacological Targets in the Gut-brain Axis

Overview

Journal Therap Adv Gastroenterol

Publisher Sage Publications

Specialty Gastroenterology

Date 2016 May 3

PMID 27134664

Citations 7

Authors

Camila Gonzalez-Arancibia

Jorge Escobar-Luna

Camila Barrera-Bugueno

Camilo Diaz-Zepeda

Maria P Gonzalez-Toro

Loreto Olavarria-Ramirez

Francesca Zanelli-Massai

Martin Gotteland

Javier A Bravo

Marcela Julio-Pieper

Affiliations

Soon will be listed here.

Abstract

The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

Citing Articles

Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats.

Al Khalaf A, Abdulrahman A, Kaleem M, Nur S, Asseri A, Choudhry H Nutrients. 2021; 13(11).

PMID: 34836145 PMC: 8618180. DOI: 10.3390/nu13113885.

Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver.

Zhou H, Xu J, Huang S, He Y, He X, Guo L J Immunol Res. 2021; 2021:6666428.

PMID: 34514001 PMC: 8429033. DOI: 10.1155/2021/6666428.

Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.

Xiao Q, Fang X, Li X, Fei G World J Gastroenterol. 2020; 26(17):2049-2063.

PMID: 32536774 PMC: 7267697. DOI: 10.3748/wjg.v26.i17.2049.

Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians.

Sinagra E, Utzeri E, Morreale G, Fabbri C, Pace F, Anderloni A World J Clin Cases. 2020; 8(6):1013-1025.

PMID: 32258072 PMC: 7103973. DOI: 10.12998/wjcc.v8.i6.1013.

Investigating Gut Permeability in Animal Models of Disease.

Gonzalez-Gonzalez M, Diaz-Zepeda C, Eyzaguirre-Velasquez J, Gonzalez-Arancibia C, Bravo J, Julio-Pieper M Front Physiol. 2019; 9:1962.

PMID: 30697168 PMC: 6341294. DOI: 10.3389/fphys.2018.01962.

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