Update on the Management of Aspirin-Exacerbated Respiratory Disease

Overview

Journal Allergy Asthma Immunol Res

Date 2016 Apr 30

PMID 27126722

Citations 17

Authors

Kathleen M Buchheit

Tanya M Laidlaw

Affiliations

Soon will be listed here.

Abstract

Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of COX-1 inhibitors, and for some patients aspirin desensitization followed by high-dose aspirin therapy. Despite this, many patients have inadequately controlled symptoms and require multiple sinus surgeries. In this review, we discuss the current standard approaches to the management of AERD, and we introduce several therapeutics under development that may hold promise for the treatment of AERD.

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