Ultraflexible Organic Amplifier with Biocompatible Gel Electrodes

Overview

Journal Nat Commun

Specialty Biology

Date 2016 Apr 30

PMID 27125910

Citations 32

Authors

Tsuyoshi Sekitani

Tomoyuki Yokota

Kazunori Kuribara

Martin Kaltenbrunner

Takanori Fukushima

Yusuke Inoue

Masaki Sekino

Takashi Isoyama

Yusuke Abe

Hiroshi Onodera

Takao Someya

Affiliations

Soon will be listed here.

Abstract

In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm(-2) and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-μm-thick polyethylene-naphthalate film to amplify (amplification factor: ∼200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue.

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