Effects of Léveille Extracts on Cadmium and Mercury Secretion As Well As Oxidative Capacity: A Randomized, Double-blind, Placebo-controlled Trial

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2016 Apr 29

PMID 27123258

Citations 4

Authors

Jae Sam Seo

Dae Young Yoo

Hyo Young Jung

Dong-Woo Kim

In Koo Hwang

Jong Young Lee

Seung Myung Moon

Affiliations

Soon will be listed here.

Abstract

In this randomized, double-blind, placebo controlled clinical trial, the effects of () Léveille on heavy metal (cadmium and mercury) excretion as well as on lipid peroxidation and Cu, Zn-superoxide dismutase (SOD1) activity were investigated. For this study, tablets containing placebo or 300 mg of the leaf extract from Léveille were used. A total of 60 eligible healthy subjects were enrolled in this randomized, double-blind, placebo-controlled study. The differences in cadmium, mercury, and malondialdehyde (MDA) levels and SOD1 activity were measured in the serum 60 days after treatment with placebo or D. morbifera Léveille extracts. No significant differences between baseline characteristics and biochemical values were identified in subjects in the placebo and D. morbifera Léveille groups. Serum levels of cadmium, mercury and MDA decreased following consumption of D. morbifera Léveille extracts; however, no significant differences were identified. In addition, female, but not male, subjects who consumed D. morbifera Léveille extracts showed a significant increase in SOD1 activity. This result suggests that chronic consumption of D. morbifera Léveille extract can help to facilitate excretion of cadmium and mercury from serum and increase the antioxidant capacity in humans.

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