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Potential Biomarkers for Esophageal Cancer

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Journal Springerplus
Date 2016 Apr 28
PMID 27119071
Citations 26
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Abstract

Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate the biomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curative effect and survival rate. Here, we reviewed the potential biomarkers of esophageal cancer in three aspects: Immunohistochemical markers, blood-based markers, miRNA markers and Gene expression profiling. All these biomarkers provided promising therapeutic targets for the diagnosis, treatment, and prognosis of esophageal cancer.

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References
1.
Lesnikova I, Lidang M, Hamilton-Dutoit S, Koch J . HER2/neu (c-erbB-2) gene amplification and protein expression are rare in uterine cervical neoplasia: a tissue microarray study of 814 archival specimens. APMIS. 2009; 117(10):737-45. DOI: 10.1111/j.1600-0463.2009.02531.x. View

2.
Dreilich M, Wanders A, Brattstrom D, Bergstrom S, Hesselius P, Wagenius G . HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival. Dis Esophagus. 2006; 19(4):224-31. DOI: 10.1111/j.1442-2050.2006.00570.x. View

3.
Uemura N, Kondo T . Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer. World J Gastrointest Pathophysiol. 2014; 5(3):322-34. PMC: 4133529. DOI: 10.4291/wjgp.v5.i3.322. View

4.
Skacel M, Petras R, Rybicki L, Gramlich T, Richter J, Falk G . p53 expression in low grade dysplasia in Barrett's esophagus: correlation with interobserver agreement and disease progression. Am J Gastroenterol. 2002; 97(10):2508-13. DOI: 10.1111/j.1572-0241.2002.06032.x. View

5.
Kilic A, Schuchert M, Luketich J, Landreneau R, Lokshin A, Bigbee W . Use of novel autoantibody and cancer-related protein arrays for the detection of esophageal adenocarcinoma in serum. J Thorac Cardiovasc Surg. 2008; 136(1):199-204. DOI: 10.1016/j.jtcvs.2008.01.012. View