Long-term Effects of Cerebral Hypoperfusion on Neural Density and Function Using Misery Perfusion Animal Model

Overview

Journal Sci Rep

Specialty Science

Date 2016 Apr 28

PMID 27116932

Citations 8

Authors

Asuka Nishino

Yosuke Tajima

Hiroyuki Takuwa

Kazuto Masamoto

Junko Taniguchi

Hidekatsu Wakizaka

Daisuke Kokuryo

Takuya Urushihata

Ichio Aoki

Iwao Kanno

Yutaka Tomita

Norihiro Suzuki

Yoko Ikoma

Hiroshi Ito

Affiliations

Soon will be listed here.

Abstract

We investigated the chronic effects of cerebral hypoperfusion on neuronal density and functional hyperemia using our misery perfusion mouse model under unilateral common carotid artery occlusion (UCCAO). Neuronal density evaluated 28 days after UCCAO using [(11)C]flumazenil-PET and histology indicated no neurologic deficit in the hippocampus and neocortex. CBF response to sensory stimulation was assessed using laser-Doppler flowmetry. Percentage changes in CBF response of the ipsilateral hemisphere to UCCAO were 18.4 ± 3.0%, 6.9 ± 2.8%, 6.8 ± 2.3% and 4.9 ± 2.4% before, and 7, 14 and 28 days after UCCAO, respectively. Statistical significance was found at 7, 14 and 28 days after UCCAO (P < 0.01). Contrary to our previous finding (Tajima et al. 2014) showing recovered CBF response to hypercapnia on 28 days after UCCAO using the same model, functional hyperemia was sustained and became worse 28 days after UCCAO.

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