Protective Effect of Crocin on Gentamicin-induced Nephrotoxicity in Rats

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2016 Apr 27

PMID 27114805

Citations 17

Authors

Zeynab Mohamadi Yarijani

Houshang Najafi

Seyed Hamid Madani

Affiliations

Soon will be listed here.

Abstract

Objectives: Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats.

Materials And Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without crocin (100 mg/kg, IP) for seven consecutive days. Plasma creatinine and urea-nitrogen concentrations, oxidative stress and histopathological changes of kidney tissues were monitored.

Results: Administration of gentamicin resulted in significant increases in plasma creatinine and urea-nitrogen concentrations and renal tissue malondialdehyde (MDA) level, and a decrease in the renal tissue ferric reducing/antioxidant power (FRAP) level. Crocin decreased plasma creatinine and urea-nitrogen concentrations and tissue MDA level, but increased the level of tissue FRAP. In addition, gentamicin led to cellular damages including glomerular atrophy, cellular desquamation, tubular necrosis and fibrosis, epithelial oedema of proximal tubules, perivascular edema, vascular congestion and intra-tubular proteinaceous casts, all of which were partially recovered by crocin.

Conclusion: Crocin has protective effects against functional disturbances, oxidative stress and tissue damages induced by gentamicin.

Citing Articles

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Potential therapeutic effects of crocin.

Pourmousavi L, Asadi R, Zehsaz F, Jadidi R Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(10):7395-7420.

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Protective role of citronellol on antioxidant enzymes and oxidative damage induced by gentamicin in experimental nephrotoxic rats.

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Crocin protects against endoplasmic reticulum stress-related tubular injury in diabetic nephropathy via the activation of the PI3K/AKT/Nrf2 pathway.

Wang G, Deng J, Hua Z Iran J Basic Med Sci. 2024; 27(4):439-446.

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Role of cineole in alleviation of acute kidney injury and renal function recovery following gentamicin administration in rats.

Rahimi Monfared S, Valibeik A, Jafaripour L, Eslamifar Z, Veiskarami S, Ahmadvand H Iran J Basic Med Sci. 2023; 26(5):504-510.

PMID: 37051098 PMC: 10083827. DOI: 10.22038/IJBMS.2023.68430.14944.

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