Age at Adiposity Rebound: Determinants and Association with Nutritional Status and the Metabolic Syndrome at Adulthood

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2016 Apr 27

PMID 27113489

Citations 31

Authors

S Peneau

R Gonzalez-Carrascosa

G Gusto

D Goxe

O Lantieri

L Fezeu

S Hercberg

M F Rolland-Cachera

Affiliations

Soon will be listed here.

Abstract

Objective: Early-life growth characteristics and in particular age at adiposity rebound (AR), have been shown to impact nutritional status later in life but studies investigating the association with long-term health remain scarce. Our aims were to identify determinants of age at AR and its relationship with nutritional status and cardiometabolic risk factors at adulthood.

Design: A total of 1465 subjects aged 20-60 years participated in this retrospective cohort study. Height, weight, waist circumference, blood glucose, lipids and blood pressure were measured at adulthood. Childhood weight, height, gestational age, birth weight and early nutrition were collected retrospectively from health booklets and age at AR was assessed. Participants self-reported parental silhouettes. Associations were assessed using multiple linear and logistic regression.

Results: An earlier AR was associated with higher body mass index and waist circumference at adulthood in both men and women (P<0.0001). In addition, women with an earlier occurrence of AR had higher triglyceride (P=0.001), low-density lipoprotein-cholesterol (P=0.001), systolic (P=0.02) and diastolic blood pressure (P=0.04) at adulthood. Both men (odds ratio (OR) (95% confidence interval (CI)): 0.82 (0.70-0.95)) and women (OR (95% CI): 0.84 (0.73-0.96) with an AR occurring earlier were more likely to develop a metabolic syndrome. Larger parental silhouette was associated with an earlier AR.

Conclusions: This long-term study showed that age at AR was associated with nutritional status and metabolic syndrome at adulthood. These results highlight the importance of monitoring childhood growth so as to help identify children at risk of developing an adverse cardiometabolic profile in adulthood. AR determinants for use in overweight surveillance were identified.

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References

Vernay M, Salanave B, de Peretti C, Druet C, Malon A, Deschamps V . Metabolic syndrome and socioeconomic status in France: The French Nutrition and Health Survey (ENNS, 2006-2007). Int J Public Health. 2013; 58(6):855-64. DOI: 10.1007/s00038-013-0501-2. View

Chivers P, Hands B, Parker H, Bulsara M, Beilin L, Kendall G . Body mass index, adiposity rebound and early feeding in a longitudinal cohort (Raine Study). Int J Obes (Lond). 2010; 34(7):1169-76. DOI: 10.1038/ijo.2010.61. View

Eriksson J . Early growth and coronary heart disease and type 2 diabetes: findings from the Helsinki Birth Cohort Study (HBCS). Am J Clin Nutr. 2011; 94(6 Suppl):1799S-1802S. DOI: 10.3945/ajcn.110.000638. View

Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D . Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life. Diabetologia. 2003; 46(2):190-4. DOI: 10.1007/s00125-002-1012-5. View

Johnson W, Soloway L, Erickson D, Choh A, Lee M, Chumlea W . A changing pattern of childhood BMI growth during the 20th century: 70 y of data from the Fels Longitudinal Study. Am J Clin Nutr. 2012; 95(5):1136-43. PMC: 3325836. DOI: 10.3945/ajcn.111.022269. View

Gunther A, Buyken A, Kroke A . The influence of habitual protein intake in early childhood on BMI and age at adiposity rebound: results from the DONALD Study. Int J Obes (Lond). 2006; 30(7):1072-9. DOI: 10.1038/sj.ijo.0803288. View

Silventoinen K, Kaprio J, Lahelma E, Viken R, Rose R . Sex differences in genetic and environmental factors contributing to body-height. Twin Res. 2001; 4(1):25-9. DOI: 10.1375/1369052012119. View

Sovio U, Kaakinen M, Tzoulaki I, Das S, Ruokonen A, Pouta A . How do changes in body mass index in infancy and childhood associate with cardiometabolic profile in adulthood? Findings from the Northern Finland Birth Cohort 1966 Study. Int J Obes (Lond). 2013; 38(1):53-9. DOI: 10.1038/ijo.2013.165. View

Ventura A, Loken E, Birch L . Developmental trajectories of girls' BMI across childhood and adolescence. Obesity (Silver Spring). 2009; 17(11):2067-74. DOI: 10.1038/oby.2009.123. View

10.

Bulik C, Wade T, Heath A, Martin N, Stunkard A, Eaves L . Relating body mass index to figural stimuli: population-based normative data for Caucasians. Int J Obes Relat Metab Disord. 2001; 25(10):1517-24. DOI: 10.1038/sj.ijo.0801742. View

11.

Magee C, Caputi P, Iverson D . Identification of distinct body mass index trajectories in Australian children. Pediatr Obes. 2012; 8(3):189-98. DOI: 10.1111/j.2047-6310.2012.00112.x. View

12.

Guo S, Huang C, Maynard L, Demerath E, Towne B, Chumlea W . Body mass index during childhood, adolescence and young adulthood in relation to adult overweight and adiposity: the Fels Longitudinal Study. Int J Obes Relat Metab Disord. 2000; 24(12):1628-35. DOI: 10.1038/sj.ijo.0801461. View

13.

Wadsworth M, Butterworth S, Marmot M, Ecob R, Hardy R . Early growth and type 2 diabetes: evidence from the 1946 British birth cohort. Diabetologia. 2005; 48(12):2505-10. DOI: 10.1007/s00125-005-0007-4. View

14.

Rolland-Cachera M, Cole T, SEMPE M, Tichet J, Rossignol C, Charraud A . Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr. 1991; 45(1):13-21. View

15.

Czernichow S, Vergnaud A, Maillard-Teyssier L, Peneau S, Bertrais S, Mejean C . Trends in the prevalence of obesity in employed adults in central-western France: a population-based study, 1995-2005. Prev Med. 2009; 48(3):262-6. DOI: 10.1016/j.ypmed.2008.12.016. View

16.

Rolland-Cachera M, Deheeger M, Maillot M, Bellisle F . Early adiposity rebound: causes and consequences for obesity in children and adults. Int J Obes (Lond). 2006; 30 Suppl 4:S11-7. DOI: 10.1038/sj.ijo.0803514. View

17.

Peneau S, Hercberg S, Rolland-Cachera M . Breastfeeding, early nutrition, and adult body fat. J Pediatr. 2014; 164(6):1363-8. DOI: 10.1016/j.jpeds.2014.02.020. View

18.

Rolland-Cachera M, Maillot M, Deheeger M, Souberbielle J, Peneau S, Hercberg S . Association of nutrition in early life with body fat and serum leptin at adult age. Int J Obes (Lond). 2012; 37(8):1116-22. DOI: 10.1038/ijo.2012.185. View

19.

Ong K . Size at birth, postnatal growth and risk of obesity. Horm Res. 2006; 65 Suppl 3:65-9. DOI: 10.1159/000091508. View

20.

Koyama S, Ichikawa G, Kojima M, Shimura N, Sairenchi T, Arisaka O . Adiposity rebound and the development of metabolic syndrome. Pediatrics. 2013; 133(1):e114-9. DOI: 10.1542/peds.2013-0966. View