TSPO Finds NOX2 in Microglia for Redox Homeostasis

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2016 Apr 27

PMID 27113160

Citations 36

Authors

Tomas R Guilarte

Meredith K Loth

Sara R Guariglia

Affiliations

Soon will be listed here.

Abstract

During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial cells. Here, we identify a novel function of TSPO in microglia that is not associated with steroidogenesis. We propose that a TSPO interaction with NADPH oxidase (NOX2) links the generation of reactive oxygen species (ROS) to the induction of an antioxidant response to maintain redox homeostasis. This line of investigation may provide a greater understanding of TSPO glial cell biology, and the knowledge gained may prove beneficial in devising therapeutic strategies.

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