Oesophageal Adenocarcinoma and Gastric Cancer: Should We Mind the Gap?

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2016 Apr 27

PMID 27112208

Citations 58

Authors

Yoku Hayakawa

Nilay Sethi

Antonia R Sepulveda

Adam J Bass

Timothy C Wang

Affiliations

Soon will be listed here.

Abstract

Over recent decades we have witnessed a shift in the anatomical distribution of gastric cancer (GC), which increasingly originates from the proximal stomach near the junction with the oesophagus. In parallel, there has been a dramatic rise in the incidence of oesophageal adenocarcinoma (OAC) in the lower oesophagus, which is associated with antecedent Barrett oesophagus (BO). In this context, there has been uncertainty regarding the characterization of adenocarcinomas spanning the area from the lower oesophagus to the distal stomach. Most relevant to this discussion is the distinction, if any, between OAC and intestinal-type GC of the proximal stomach. It is therefore timely to review our current understanding of OAC and intestinal-type GC, integrating advances from cell-of-origin studies and comprehensive genomic alteration analyses, ultimately enabling better insight into the relationship between these two cancers.

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