Characterization of Embryonic Stem Cell Model of Polycystic Ovary Syndrome

Overview

Journal In Vitro Cell Dev Biol Anim

Publisher Springer

Specialties Biology
Cell Biology

Date 2016 Apr 27

PMID 27112161

Citations 1

Authors

Yue Zhang

Yun-Shan Zhang

Feng-Xia Xue

Affiliations

Soon will be listed here.

Abstract

The aims of this study are to establish an embryonic stem (ES) cell model of polycystic ovary syndrome and to characterize this ES cell line. ES cells were isolated and cultured from 322 wasted fertilized embryos from polycystic ovary syndrome (PCOS) patients in vitro. They were also characterized by development and differential markers. ES cells from PCOS subject present normal development profile with ES-specific markers such as OCT-4 and SSEA-4. These ES cells can also differentiate into three germ layer derivatives and form teratomas in vivo. ES cells from PCOS patients pose development and differentiation potentials as you would expect of cells from non-PCOS patients; therefore, they can be used as a cellular model to study the pathology of PCOS.

Citing Articles

Induced Pluripotent Stem Cells as a Possible Approach for Exploring the Pathophysiology of Polycystic Ovary Syndrome (PCOS).

Khatun M, Lundin K, Naillat F, Loog L, Saarela U, Tuuri T Stem Cell Rev Rep. 2023; 20(1):67-87.

PMID: 37768523 PMC: 10799779. DOI: 10.1007/s12015-023-10627-w.

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