Effects of Combined Training Vs Aerobic Training on Cognitive Functions in COPD: a Randomized Controlled Trial

Overview

Journal Int J Chron Obstruct Pulmon Dis

Publisher Dove Medical Press

Specialty Pulmonary Medicine

Date 2016 Apr 26

PMID 27110107

Citations 16

Authors

Giovanna Aquino

Enzo Iuliano

Alessandra di Cagno

Angela Vardaro

Giovanni Fiorilli

Stefano Moffa

Alfonso di Costanzo

Giuseppe De Simone

Giuseppe Calcagno

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this study was to investigate the effects of high-intensity aerobic training (AT) and high-intensity aerobic training combined with resistance training (ie, combined training [CT]) on cognitive function in patients with COPD.

Methods: Twenty-eight Caucasian male patients (68.35±9.64 years; mean ± SD) with COPD were recruited and randomized into two groups, AT and CT. Both groups performed physical reconditioning for 4 weeks, with a frequency of five training sessions per week. The CT group completed two daily sessions of 30 minutes: one aerobic session and one strength session, respectively; The AT group performed two 30-minute aerobic endurance exercise sessions on treadmill. Physical and cognitive function tests were performed before and after the training intervention performances.

Results: Exercise training improved the following cognitive functions: long-term memory, verbal fluency, attentional capacity, apraxia, and reasoning skills (P<0.01). Moreover, the improvements in the CT group were significantly greater than those in the AT group in long-term memory, apraxia, and reasoning skills (P<0.05).

Conclusion: CT may be a possible strategy to prevent cognitive decline and associated comorbidities in male patients with COPD.

Citing Articles

Impact of exercise training on cognitive function in patients with COPD: a systematic review and meta-analysis of randomised controlled trials.

Ding K, Song F, Sun W, Sun M, Xia R Eur Respir Rev. 2025; 34(175).

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Effects of different exercise regimens on prognosis of patients with chronic obstructive pulmonary disease: a systematic reviews and meta-analysis.

Zhang Z, Li Y Ann Med. 2024; 56(1):2392022.

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Impact of cognitive capacity on physical performance in chronic obstructive pulmonary disease patients: A scoping review.

Rassam P, Pazzianotto-Forti E, Matsumura U, Orchanian-Cheff A, Aliabadi S, Kulkarni M Chron Respir Dis. 2023; 20:14799731231163874.

PMID: 37029090 PMC: 10087654. DOI: 10.1177/14799731231163874.

Preliminary study of assessing cognitive impairment in older patients with chronic obstructive pulmonary disease by using a cognitive functional assessment tool via a touchscreen personal computer.

Ogawa M, Uchiumi A, Sato S, Hamakawa Y, Kobashi M, Aoyama T Multidiscip Respir Med. 2023; 18:892.

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The role of structured exercise interventions on cognitive function in older individuals with stable Chronic Obstructive Pulmonary Disease: A scoping review.

Eastus C, Baez D, Buckley M, Lee J, Adami A Front Rehabil Sci. 2022; 3:987356.

PMID: 36386775 PMC: 9659625. DOI: 10.3389/fresc.2022.987356.

References

Etnier J, Johnston R, Dagenbach D, Pollard R, Rejeski W, Berry M . The relationships among pulmonary function, aerobic fitness, and cognitive functioning in older COPD patients. Chest. 1999; 116(4):953-60. DOI: 10.1378/chest.116.4.953. View

Zambom-Ferraresi F, Cebollero P, Gorostiaga E, Hernandez M, Hueto J, Cascante J . Effects of Combined Resistance and Endurance Training Versus Resistance Training Alone on Strength, Exercise Capacity, and Quality of Life in Patients With COPD. J Cardiopulm Rehabil Prev. 2015; 35(6):446-53. DOI: 10.1097/HCR.0000000000000132. View

Raven J . The Raven's progressive matrices: change and stability over culture and time. Cogn Psychol. 2000; 41(1):1-48. DOI: 10.1006/cogp.1999.0735. View

WEICKER H, Struder H . Influence of exercise on serotonergic neuromodulation in the brain. Amino Acids. 2001; 20(1):35-47. DOI: 10.1007/s007260170064. View

Pauwels R, Buist A, Calverley P, Jenkins C, Hurd S . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001; 163(5):1256-76. DOI: 10.1164/ajrccm.163.5.2101039. View

Etnier J, Berry M . Fluid intelligence in an older COPD sample after short- or long-term exercise. Med Sci Sports Exerc. 2001; 33(10):1620-8. DOI: 10.1097/00005768-200110000-00002. View

Meek P, Lareau S, Anderson D . Memory for symptoms in COPD patients: how accurate are their reports?. Eur Respir J. 2001; 18(3):474-81. DOI: 10.1183/09031936.01.00083501. View

Wouters E, Creutzberg E, Schols A . Systemic effects in COPD. Chest. 2002; 121(5 Suppl):127S-130S. DOI: 10.1378/chest.121.5_suppl.127s. View

Aagaard P, Simonsen E, Andersen J, Magnusson P, Dyhre-Poulsen P . Neural adaptation to resistance training: changes in evoked V-wave and H-reflex responses. J Appl Physiol (1985). 2002; 92(6):2309-18. DOI: 10.1152/japplphysiol.01185.2001. View

10.

Churchill J, Galvez R, Colcombe S, Swain R, Kramer A, Greenough W . Exercise, experience and the aging brain. Neurobiol Aging. 2002; 23(5):941-55. DOI: 10.1016/s0197-4580(02)00028-3. View

11.

Kozora E, Tran Z, Make B . Neurobehavioral improvement after brief rehabilitation in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2002; 22(6):426-30. DOI: 10.1097/00008483-200211000-00008. View

12.

Antonelli Incalzi R, Marra C, Giordano A, Calcagni M, Cappa A, Basso S . Cognitive impairment in chronic obstructive pulmonary disease--a neuropsychological and spect study. J Neurol. 2003; 250(3):325-32. DOI: 10.1007/s00415-003-1005-4. View

13.

Peruzza S, Sergi G, Vianello A, Pisent C, Tiozzo F, Manzan A . Chronic obstructive pulmonary disease (COPD) in elderly subjects: impact on functional status and quality of life. Respir Med. 2003; 97(6):612-7. DOI: 10.1053/rmed.2003.1488. View

14.

McMorris T, Tallon M, Williams C, Sproule J, Draper S, Swain J . Incremental exercise, plasma concentrations of catecholamines, reaction time, and motor time during performance of a noncompatible choice response time task. Percept Mot Skills. 2003; 97(2):590-604. DOI: 10.2466/pms.2003.97.2.590. View

15.

Emery C, Shermer R, Hauck E, Hsiao E, MacIntyre N . Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease. Health Psychol. 2003; 22(6):598-604. DOI: 10.1037/0278-6133.22.6.598. View

16.

Liesker J, Postma D, Beukema R, Ten Hacken N, van der Molen T, Riemersma R . Cognitive performance in patients with COPD. Respir Med. 2004; 98(4):351-6. DOI: 10.1016/j.rmed.2003.11.004. View

17.

Caltagirone C, Gainotti G, Masullo C, Miceli G . Validity of some neuropsychological tests in the assessment of mental deterioration. Acta Psychiatr Scand. 1979; 60(1):50-6. DOI: 10.1111/j.1600-0447.1979.tb00264.x. View

18.

Kaszniak A, Garron D, Fox J, Bergen D, Huckman M . Cerebral atrophy, EEG slowing age, education, and cognitive functioning in suspected dementia. Neurology. 1979; 29(9 Pt 1):1273-9. DOI: 10.1212/wnl.29.9_part_1.1273. View

19.

Grant I, Heaton R, McSweeny A, Adams K, Timms R . Neuropsychologic findings in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med. 1982; 142(8):1470-6. View

20.

Gold P, Zornetzer S . The mnemon and its juices: neuromodulation of memory processes. Behav Neural Biol. 1983; 38(2):151-89. DOI: 10.1016/s0163-1047(83)90170-x. View