Adenoviral Vector-based Strategies Against Infectious Disease and Cancer

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2016 Apr 23

PMID 27105067

Citations 57

Authors

Chao Zhang

Dongming Zhou

Affiliations

Soon will be listed here.

Abstract

Adenoviral vectors are widely employed against infectious diseases or cancers, as they can elicit specific antibody responses and T cell responses when they are armed with foreign genes as vaccine carriers, and induce apoptosis of the cancer cells when they are genetically modified for cancer therapy. In this review, we summarize the biological characteristics of adenovirus (Ad) and the latest development of Ad vector-based strategies for the prevention and control of emerging infectious diseases or cancers. Strategies to circumvent the pre-existing neutralizing antibodies which dampen the immunogenicity of Ad-based vaccines are also discussed.

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References

Liikanen I, Ahtiainen L, Hirvinen M, Bramante S, Cerullo V, Nokisalmi P . Oncolytic adenovirus with temozolomide induces autophagy and antitumor immune responses in cancer patients. Mol Ther. 2013; 21(6):1212-23. PMC: 3681222. DOI: 10.1038/mt.2013.51. View

Xiang Z, Greenberg L, Ertl H, Rupprecht C . Protection of non-human primates against rabies with an adenovirus recombinant vaccine. Virology. 2014; 450-451:243-9. PMC: 4038128. DOI: 10.1016/j.virol.2013.12.029. View

Sullivan N, Sanchez A, Rollin P, Yang Z, Nabel G . Development of a preventive vaccine for Ebola virus infection in primates. Nature. 2000; 408(6812):605-9. DOI: 10.1038/35046108. View

Takafuji E, Gaydos J, Allen R, Top Jr F . Simultaneous administration of live, enteric-coated adenovirus types 4, 7 and 21 vaccines: safety and immunogenicity. J Infect Dis. 1979; 140(1):48-53. DOI: 10.1093/infdis/140.1.48. View

Peters W, Brandl J, Lindbloom J, Martinez C, Scallan C, Trager G . Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans. Vaccine. 2013; 31(13):1752-8. DOI: 10.1016/j.vaccine.2013.01.023. View

Vemula S, Ahi Y, Swaim A, Katz J, Donis R, Sambhara S . Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness. PLoS One. 2013; 8(4):e62496. PMC: 3640067. DOI: 10.1371/journal.pone.0062496. View

Sachs M, Rauen K, Ramamurthy M, Dodson J, De Marzo A, Putzi M . Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer. Urology. 2002; 60(3):531-6. DOI: 10.1016/s0090-4295(02)01748-x. View

Karen K, Deal C, Adams R, Nielsen C, Ward C, Espinosa D . A replicating adenovirus capsid display recombinant elicits antibodies against Plasmodium falciparum sporozoites in Aotus nancymaae monkeys. Infect Immun. 2014; 83(1):268-75. PMC: 4288877. DOI: 10.1128/IAI.02626-14. View

Schnurr D . Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues. J Virol. 1996; 70(3):1836-44. PMC: 190011. DOI: 10.1128/JVI.70.3.1836-1844.1996. View

10.

Yeh P, Dedieu J, Orsini C, Vigne E, Denefle P, Perricaudet M . Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J Virol. 1996; 70(1):559-65. PMC: 189844. DOI: 10.1128/JVI.70.1.559-565.1996. View

11.

Sharma A, Krause A, Xu Y, Sung B, Wu W, Worgall S . Adenovirus-based vaccine with epitopes incorporated in novel fiber sites to induce protective immunity against Pseudomonas aeruginosa. PLoS One. 2013; 8(2):e56996. PMC: 3577763. DOI: 10.1371/journal.pone.0056996. View

12.

Havenga M, Holterman L, Melis I, Smits S, Kaspers J, Heemskerk E . Serum-free transient protein production system based on adenoviral vector and PER.C6 technology: high yield and preserved bioactivity. Biotechnol Bioeng. 2008; 100(2):273-83. PMC: 7161845. DOI: 10.1002/bit.21757. View

13.

Lasaro M, Ertl H . New insights on adenovirus as vaccine vectors. Mol Ther. 2009; 17(8):1333-9. PMC: 2835230. DOI: 10.1038/mt.2009.130. View

14.

Choi J, Schafer S, Zhang L, Kobinger G, Juelich T, Freiberg A . A single sublingual dose of an adenovirus-based vaccine protects against lethal Ebola challenge in mice and guinea pigs. Mol Pharm. 2011; 9(1):156-67. PMC: 3358355. DOI: 10.1021/mp200392g. View

15.

Ariyoshi Y, Watanabe M, Eikawa S, Yamazaki C, Sadahira T, Hirata T . The induction of antigen-specific CTL by in situ Ad-REIC gene therapy. Gene Ther. 2016; 23(5):408-14. DOI: 10.1038/gt.2016.7. View

16.

Ledgerwood J, Costner P, Desai N, Holman L, Enama M, Yamshchikov G . A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults. Vaccine. 2010; 29(2):304-13. DOI: 10.1016/j.vaccine.2010.10.037. View

17.

Wong G, Richardson J, Pillet S, Racine T, Patel A, Soule G . Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates. J Infect Dis. 2015; 212 Suppl 2:S379-83. PMC: 4564535. DOI: 10.1093/infdis/jiv102. View

18.

Prevec L, Campbell J, Christie B, Belbeck L, Graham F . A recombinant human adenovirus vaccine against rabies. J Infect Dis. 1990; 161(1):27-30. DOI: 10.1093/infdis/161.1.27. View

19.

Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z . Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71. Vaccine. 2015; 33(39):5087-94. DOI: 10.1016/j.vaccine.2015.08.016. View

20.

Wickham T, Carrion M, Kovesdi I . Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs. Gene Ther. 1995; 2(10):750-6. View