Enhancing Pathogen Identification in Patients with Meningitis and a Negative Gram Stain Using the BioFire FilmArray(®) Meningitis/Encephalitis Panel

Overview

Journal Ann Clin Microbiol Antimicrob

Publisher Biomed Central

Specialties Infectious Diseases
Microbiology

Date 2016 Apr 23

PMID 27101869

Citations 25

Authors

Susan H Wootton

Elizabeth Aguilera

Lucrecia Salazar

Andrew C Hemmert

Rodrigo Hasbun

Affiliations

Soon will be listed here.

Abstract

Background: Meningitis with a negative cerebrospinal (CSF) Gram stain represents a diagnostic and therapeutic challenge. The purpose of our study was to evaluate the performance of the BioFire FilmArray(®) Meningitis/Encephalitis (FA ME) panel in patients presenting with community-acquired meningitis with a negative Gram stain.

Methods: CSF from 48 patients with community-acquired meningitis with a negative Gram stain admitted to four hospitals in Houston, TX underwent additional testing by the FA ME. FA ME results were compared to results obtained as part of routine evaluation.

Results: The panel detected pathogens not previously identified in 11 (22.9 %) of 48, but did not detect pathogens identified by standard technique (West Nile virus, Histoplasma) in 5 (15.2 %) patients.

Conclusions: Rapid testing for the most common pathogens causing meningitis will aid in the diagnosis and treatment of patients with meningitis.

Citing Articles

Comparison of positive BioFire FilmArray meningitis/encephalitis (ME) panels, CSF cultures, CSF parameters, clinical presentation and in-patient mortality among patients with bacterial and fungal meningitis.

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A multicenter evaluation of the QIAstat-Dx meningitis-encephalitis syndromic test kit as compared to the conventional diagnostic microbiology workflow.

Boers S, van Houdt R, Van Sorge N, Groot J, van Aarle Y, van Bussel M Eur J Clin Microbiol Infect Dis. 2024; 43(3):511-516.

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Masri A, Dwaikat A, Haroun N, Haikal L, Kharabsheh M, Daher A Cureus. 2022; 14(4):e24383.

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