A Brain System for Auditory Working Memory

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Apr 22

PMID 27098693

Citations 86

Authors

Sukhbinder Kumar

Sabine Joseph

Phillip E Gander

Nicolas Barascud

Andrea R Halpern

Timothy D Griffiths

Affiliations

Soon will be listed here.

Abstract

Significance Statement: In this work, we demonstrate a system for maintaining sound in working memory based on activity in auditory cortex, hippocampus, and frontal cortex, and functional connectivity among them. Specifically, our work makes three advances from the previous work. First, we robustly demonstrate hippocampal involvement in all phases of auditory working memory (encoding, maintenance, and retrieval): the role of hippocampus in working memory is controversial. Second, using a pattern classification technique, we show that activity in the auditory cortex and inferior frontal gyrus is specific to the maintained tones in working memory. Third, we show long-range connectivity of auditory cortex to hippocampus and frontal cortex, which may be responsible for keeping such representations active during working memory maintenance.

Citing Articles

Decoding auditory working memory content from EEG aftereffects of auditory-cortical TMS.

Uluc I, Daneshzand M, Jas M, Kotlarz P, Lankinen K, Fiedler J bioRxiv. 2025; .

PMID: 39975364 PMC: 11838191. DOI: 10.1101/2024.03.04.583379.

A hybrid critical channels and optimal feature subset selection framework for EEG fatigue recognition.

Guo H, Chen S, Zhou Y, Xu T, Zhang Y, Ding H Sci Rep. 2025; 15(1):2139.

PMID: 39819993 PMC: 11739579. DOI: 10.1038/s41598-025-86234-1.

Comparing auditory and visual aspects of multisensory working memory using bimodally matched feature patterns.

Uluc I, Turpin T, Kotlarz P, Lankinen K, Mamashli F, Ahveninen J Exp Brain Res. 2024; 243(1):38.

PMID: 39738596 PMC: 11848833. DOI: 10.1007/s00221-024-06991-9.

Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams, respectively.

Matchin W, Mollasaraei Z, Bonilha L, Rorden C, Hickok G, den Ouden D Brain Commun. 2024; 6(6):fcae449.

PMID: 39713237 PMC: 11660927. DOI: 10.1093/braincomms/fcae449.

Language aptitude is related to the anatomy of the transverse temporal gyri.

Ramoser C, Fischer A, Caspers J, Schiller N, Golestani N, Kepinska O Brain Struct Funct. 2024; 230(1):14.

PMID: 39702671 PMC: 11659347. DOI: 10.1007/s00429-024-02883-4.

References

Munoz-Lopez M, Mohedano-Moriano A, Insausti R . Anatomical pathways for auditory memory in primates. Front Neuroanat. 2010; 4:129. PMC: 2957958. DOI: 10.3389/fnana.2010.00129. View

Linke A, Vicente-Grabovetsky A, Cusack R . Stimulus-specific suppression preserves information in auditory short-term memory. Proc Natl Acad Sci U S A. 2011; 108(31):12961-6. PMC: 3150893. DOI: 10.1073/pnas.1102118108. View

Strand F, Forssberg H, Klingberg T, Norrelgen F . Phonological working memory with auditory presentation of pseudo-words -- an event related fMRI Study. Brain Res. 2008; 1212:48-54. DOI: 10.1016/j.brainres.2008.02.097. View

Gazzaley A, Rissman J, DEsposito M . Functional connectivity during working memory maintenance. Cogn Affect Behav Neurosci. 2005; 4(4):580-99. DOI: 10.3758/cabn.4.4.580. View

Axmacher N, Henseler M, Jensen O, Weinreich I, Elger C, Fell J . Cross-frequency coupling supports multi-item working memory in the human hippocampus. Proc Natl Acad Sci U S A. 2010; 107(7):3228-33. PMC: 2840289. DOI: 10.1073/pnas.0911531107. View

Aron A, Robbins T, Poldrack R . Inhibition and the right inferior frontal cortex: one decade on. Trends Cogn Sci. 2014; 18(4):177-85. DOI: 10.1016/j.tics.2013.12.003. View

McNab F, Leroux G, Strand F, Thorell L, Bergman S, Klingberg T . Common and unique components of inhibition and working memory: an fMRI, within-subjects investigation. Neuropsychologia. 2008; 46(11):2668-82. DOI: 10.1016/j.neuropsychologia.2008.04.023. View

Makovsik T, Jiang Y . Distributing versus focusing attention in visual short-term memory. Psychon Bull Rev. 2008; 14(6):1072-8. DOI: 10.3758/bf03193093. View

Haynes J, Rees G . Decoding mental states from brain activity in humans. Nat Rev Neurosci. 2006; 7(7):523-34. DOI: 10.1038/nrn1931. View

10.

Behzadi Y, Restom K, Liau J, Liu T . A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage. 2007; 37(1):90-101. PMC: 2214855. DOI: 10.1016/j.neuroimage.2007.04.042. View

11.

Shivde G, Thompson-Schill S . Dissociating semantic and phonological maintenance using fMRI. Cogn Affect Behav Neurosci. 2004; 4(1):10-9. DOI: 10.3758/cabn.4.1.10. View

12.

Axmacher N, Lenz S, Haupt S, Elger C, Fell J . Electrophysiological signature of working and long-term memory interaction in the human hippocampus. Eur J Neurosci. 2010; 31(1):177-88. DOI: 10.1111/j.1460-9568.2009.07041.x. View

13.

Salazar R, Dotson N, Bressler S, Gray C . Content-specific fronto-parietal synchronization during visual working memory. Science. 2012; 338(6110):1097-100. PMC: 4038369. DOI: 10.1126/science.1224000. View

14.

Rugg M, Vilberg K . Brain networks underlying episodic memory retrieval. Curr Opin Neurobiol. 2012; 23(2):255-60. PMC: 3594562. DOI: 10.1016/j.conb.2012.11.005. View

15.

DEsposito M, Postle B . The cognitive neuroscience of working memory. Annu Rev Psychol. 2014; 66:115-42. PMC: 4374359. DOI: 10.1146/annurev-psych-010814-015031. View

16.

Axmacher N, Mormann F, Fernandez G, Cohen M, Elger C, Fell J . Sustained neural activity patterns during working memory in the human medial temporal lobe. J Neurosci. 2007; 27(29):7807-16. PMC: 6672876. DOI: 10.1523/JNEUROSCI.0962-07.2007. View

17.

Norman K, Polyn S, Detre G, Haxby J . Beyond mind-reading: multi-voxel pattern analysis of fMRI data. Trends Cogn Sci. 2006; 10(9):424-30. DOI: 10.1016/j.tics.2006.07.005. View

18.

Mason M, Norton M, Van Horn J, Wegner D, Grafton S, Neil Macrae C . Wandering minds: the default network and stimulus-independent thought. Science. 2007; 315(5810):393-5. PMC: 1821121. DOI: 10.1126/science.1131295. View

19.

Lepage M, Habib R, Tulving E . Hippocampal PET activations of memory encoding and retrieval: the HIPER model. Hippocampus. 1998; 8(4):313-22. DOI: 10.1002/(SICI)1098-1063(1998)8:4<313::AID-HIPO1>3.0.CO;2-I. View

20.

Chadwick M, Bonnici H, Maguire E . Decoding information in the human hippocampus: a user's guide. Neuropsychologia. 2012; 50(13):3107-21. PMC: 3500691. DOI: 10.1016/j.neuropsychologia.2012.07.007. View