Optogenetic Control of Human Neurons in Organotypic Brain Cultures

Overview

Journal Sci Rep

Specialty Science

Date 2016 Apr 22

PMID 27098488

Citations 36

Authors

My Andersson

Natalia Avaliani

Andreas Svensson

Jenny Wickham

Lars H Pinborg

Bo Jespersen

Soren H Christiansen

Johan Bengzon

David P D Woldbye

Merab Kokaia

Affiliations

Soon will be listed here.

Abstract

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

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