Mechanisms of Mitophagy: PINK1, Parkin, USP30 and Beyond

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 2016 Apr 21

PMID 27094585

Citations 130

Authors

Baris Bingol

Morgan Sheng

Affiliations

Soon will be listed here.

Abstract

Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. In this pathway, PINK1 senses mitochondrial damage and activates Parkin by phosphorylating Parkin and ubiquitin. Activated Parkin then builds ubiquitin chains on damaged mitochondria to tag them for degradation in lysosomes. USP30 deubiquitinase acts as a brake on mitophagy by opposing Parkin-mediated ubiquitination. Human genetic data point to a role for mitophagy defects in neurodegenerative diseases. This review highlights the molecular mechanisms of the mitophagy pathway and the recent advances in the understanding of mitophagy in vivo.

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