Serum Chemerin and High-sensitivity C Reactive Protein As Markers of Subclinical Atherosclerosis in Egyptian Patients with Type 2 Diabetes

Overview

Journal Ther Adv Endocrinol Metab

Specialty Endocrinology

Date 2016 Apr 20

PMID 27092230

Citations 19

Authors

Nagwa A Lachine

Abdel Aziz Elnekiedy

Magdy Helmy Megallaa

Gihane I Khalil

Mohamed A Sadaka

Kamel H Rohoma

Heba S Kassab

Affiliations

Soon will be listed here.

Abstract

Context: Chemerin is one of the adipokines that regulate fat metabolism. High-sensitivity C-reactive protein (hs-CRP) may be considered as a cardiovascular risk predictor. Measuring intima-media thickness of the CCA (C-IMT) is a well-evidenced tool for the detection of early stages of atherosclerosis. We aimed here to study both serum chemerin and hs-CRP as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes, who are angiographically free of coronary artery disease (CAD).

Subjects And Methods: This cross-sectional study was conducted on 180 subjects divided into two groups: Group A included 90 type 2 diabetic patients without CAD and group B including 90 nondiabetic control subjects. All study subjects were having normal coronary angiography. Serum chemerin, homeostasis model assessment for insulin resistance (HOMA-IR), glycated haemoglobin (HbA1c), lipid profile, hs-CRP as well as C-IMT were assessed in all study subjects.

Results: There was a statistically significant difference between the 2 groups regarding serum chemerin level, HOMA-IR, hs-CRP and C-IMT; being higher in the diabetic patients than in the control group (p = 0.006, 0.024, 0.040 and <0.001, respectively). There was positive correlation between serum chemerin level and waist-to-hip ratio (WHR), HOMA-IR, hs-CRP and C-IMT. Carotid intima-media thickness was positively correlated with patients' WHR, blood pressure, HbA1c, diabetes duration as well as hs-CRP, and negatively correlated with ankle-brachial index (ABI). Linear regression analysis showed that HbA1c, serum chemerin and hs-CRP were independently affecting C-IMT. Serum hs-CRP was positively correlated with HbA1c and HOMA-IR (p = 0.006 and 0.032, respectively), and negatively correlated with HDL-cholesterol level (p = 0.018).

Conclusion: Both serum chemerin and hs-CRP could be considered as markers of subclinical atherosclerosis, and hence, may be utilized for the early detection of macrovascular disease, in Egyptian patients with type 2 diabetes.

Citing Articles

Systematic review and meta-analysis assessing the status of carotid intima-media thickness and lipid profiles in type 2 diabetes mellitus.

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Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction.

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Association of plasma chemerin with all-cause and disease-specific mortality - results from a population-based study.

Noppes K, Gross S, Hannemann A, Markus M, Bahls M, Volzke H Int J Obes (Lond). 2023; 47(10):956-962.

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Role of Chemerin in Cardiovascular Diseases.

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