Relationship Between Macular Pigment and Visual Function in Subjects with Early Age-related Macular Degeneration

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 2016 Apr 20

PMID 27091854

Citations 14

Authors

Kwadwo Owusu Akuffo

John M Nolan

Tunde Peto

Jim Stack

Irene Leung

Laura Corcoran

Stephen Beatty

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the relationship between macular pigment (MP) and visual function in subjects with early age-related macular degeneration (AMD).

Methods: 121 subjects with early AMD enrolled as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787) were assessed using a range of psychophysical measures of visual function, including best corrected visual acuity (BCVA), letter contrast sensitivity (CS), mesopic and photopic CS, mesopic and photopic glare disability (GD), photostress recovery time (PRT), reading performance and subjective visual function, using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). MP was measured using customised heterochromatic flicker photometry.

Results: Letter CS, mesopic and photopic CS, photopic GD and mean reading speed were each significantly (p<0.05) associated with MP across a range of retinal eccentricities, and these statistically significant relationships persisted after controlling for age, sex and cataract grade. BCVA, NEI VFQ-25 score, PRT and mesopic GD were unrelated to MP after controlling for age, sex and cataract grade (p>0.05, for all).

Conclusions: MP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition.

Trial Registration Number: ISRCTN13894787.

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References

Stringham J, Hammond B . Macular pigment and visual performance under glare conditions. Optom Vis Sci. 2008; 85(2):82-8. DOI: 10.1097/OPX.0b013e318162266e. View

Stringham J, Hammond Jr B . The glare hypothesis of macular pigment function. Optom Vis Sci. 2007; 84(9):859-64. DOI: 10.1097/OPX.0b013e3181559c2b. View

Hammond Jr B, Wooten B, Engles M, Wong J . The influence of filtering by the macular carotenoids on contrast sensitivity measured under simulated blue haze conditions. Vision Res. 2012; 63:58-62. DOI: 10.1016/j.visres.2012.04.019. View

Loughman J, Akkali M, Beatty S, Scanlon G, Davison P, ODwyer V . The relationship between macular pigment and visual performance. Vision Res. 2010; 50(13):1249-56. DOI: 10.1016/j.visres.2010.04.009. View

Mainster M, Turner P . Glare's causes, consequences, and clinical challenges after a century of ophthalmic study. Am J Ophthalmol. 2012; 153(4):587-93. DOI: 10.1016/j.ajo.2012.01.008. View

Renzi L, Hammond B . The effect of macular pigment on heterochromatic luminance contrast. Exp Eye Res. 2010; 91(6):896-900. DOI: 10.1016/j.exer.2010.09.015. View

Stringham J, Garcia P, Smith P, McLin L, K Foutch B . Macular pigment and visual performance in glare: benefits for photostress recovery, disability glare, and visual discomfort. Invest Ophthalmol Vis Sci. 2011; 52(10):7406-15. DOI: 10.1167/iovs.10-6699. View

Renzi L, Bovier E, Hammond Jr B . A role for the macular carotenoids in visual motor response. Nutr Neurosci. 2013; 16(6):262-8. DOI: 10.1179/1476830513Y.0000000054. View

Akuffo K, Nolan J, Howard A, Moran R, Stack J, Klein R . Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye (Lond). 2015; 29(7):902-12. PMC: 4506345. DOI: 10.1038/eye.2015.64. View

10.

Puell M, Palomo-Alvarez C, Barrio A, Gomez-Sanz F, Perez-Carrasco M . Relationship between macular pigment and visual acuity in eyes with early age-related macular degeneration. Acta Ophthalmol. 2013; 91(4):e298-303. DOI: 10.1111/aos.12067. View

11.

Johnson E . A possible role for lutein and zeaxanthin in cognitive function in the elderly. Am J Clin Nutr. 2012; 96(5):1161S-5S. DOI: 10.3945/ajcn.112.034611. View

12.

Bansback N, Czoski-Murray C, Carlton J, Lewis G, Hughes L, Espallargues M . Determinants of health related quality of life and health state utility in patients with age related macular degeneration: the association of contrast sensitivity and visual acuity. Qual Life Res. 2006; 16(3):533-43. DOI: 10.1007/s11136-006-9126-8. View

13.

Stringham J, Hammond B, Nolan J, Wooten B, Mammen A, Smollon W . The utility of using customized heterochromatic flicker photometry (cHFP) to measure macular pigment in patients with age-related macular degeneration. Exp Eye Res. 2008; 87(5):445-53. DOI: 10.1016/j.exer.2008.08.005. View

14.

Hassell J, Lamoureux E, Keeffe J . Impact of age related macular degeneration on quality of life. Br J Ophthalmol. 2006; 90(5):593-6. PMC: 1857044. DOI: 10.1136/bjo.2005.086595. View

15.

Putnam C, Bassi C . Macular pigment spatial distribution effects on glare disability. J Optom. 2015; 8(4):258-65. PMC: 4591422. DOI: 10.1016/j.optom.2014.12.004. View

16.

Slakter J, Stur M . Quality of life in patients with age-related macular degeneration: impact of the condition and benefits of treatment. Surv Ophthalmol. 2005; 50(3):263-73. DOI: 10.1016/j.survophthal.2005.02.007. View

17.

Craft N, Haitema T, Garnett K, FITCH K, Dorey C . Carotenoid, tocopherol, and retinol concentrations in elderly human brain. J Nutr Health Aging. 2004; 8(3):156-62. View

18.

Kelly D, Coen R, Akuffo K, Beatty S, Dennison J, Moran R . Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids. J Alzheimers Dis. 2015; 48(1):261-77. PMC: 4923753. DOI: 10.3233/JAD-150199. View

19.

Hammond Jr B, Fletcher L, Elliott J . Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin. Invest Ophthalmol Vis Sci. 2012; 54(1):476-81. DOI: 10.1167/iovs.12-10411. View

20.

Akuffo K, Beatty S, Stack J, Dennison J, ORegan S, Meagher K . Central Retinal Enrichment Supplementation Trials (CREST): design and methodology of the CREST randomized controlled trials. Ophthalmic Epidemiol. 2014; 21(2):111-23. PMC: 4002658. DOI: 10.3109/09286586.2014.888085. View