Zika Virus NS1 Structure Reveals Diversity of Electrostatic Surfaces Among Flaviviruses

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2016 Apr 19

PMID 27088990

Citations 92

Authors

Hao Song

Jianxun Qi

Joel Haywood

Yi Shi

George F Gao

Affiliations

Soon will be listed here.

Abstract

The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.

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