The Impact of High Progesterone Levels in the Follicular Phase of in Vitro Fertilization (IVF) Cycles: a Comparative Study

Overview

Journal J In Vitro Fert Embryo Transf

Specialty Reproductive Medicine

Date 1989 Feb 1

PMID 2708871

Citations 10

Authors

D Feldberg

G A Goldman

J Ashkenazi

D Dicker

M Shelef

J A Goldman

Affiliations

Soon will be listed here.

Abstract

Estrogen (E2) and plasma progesterone (P4) levels are valuable parameters for follicular development in in vitro fertilization (IVF) cycles. Furthermore, the progesterone concentration prior to, during, and following human chorionic gonadotropin (hCG) administration is an important marker for the detection of early luteinization and premature ovulation. The pattern of hormonal profile in relation to the number of oocytes retrieved, fertilized, and cleaved and the fate of the pregnancies achieved were compared in three groups of patients treated by the same protocol. Group I included 22 women who conceived with high progesterone levels on day hCG + 1 (P4, greater than 2.5 ng/ml). Group II included 43 women who conceived with low P4 values (P4, less than 2.5 ng/ml), while group III included 46 patients in whom no pregnancies occurred. A significant decrease in fertilization, cleavage, and pregnancy rates was observed in patients with high progesterone levels on day hCG + 1, compared to those with normal levels. Nevertheless, it is suggested that cycles with high P4 levels in the preovulatory phase should not be canceled, as a fair chance for pregnancy still exists.

Citing Articles

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The Role of Bone Morphogenetic Protein 4 in Ovarian Function and Diseases.

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Adverse effect of prematurely elevated progesterone in in vitro fertilization cycles: a literature review.

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STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells.

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