Production and Clinical Development of Nanoparticles for Gene Delivery

Overview

Journal Mol Ther Methods Clin Dev

Publisher Cell Press

Date 2016 Apr 19

PMID 27088105

Citations 89

Authors

Jie Chen

Zhaopei Guo

Huayu Tian

Xuesi Chen

Affiliations

Soon will be listed here.

Abstract

Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted. Several promising candidates, which are closest to clinical applications, will be briefly reviewed. Then, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized. Finally, the development of nanoparticles for clinical gene delivery in future will be prospected.

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