Vitamin D Status in Mothers with Pre-eclampsia and Their Infants: a Case-control Study from Serbia, a Country Without a Vitamin D Fortification Policy

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2016 Apr 19

PMID 27087002

Citations 9

Authors

Marija Djekic-Ivankovic

Hope Weiler

Glenville Jones

Martin Kaufmann

Jovana Kaludjerovic

Vesna Aleksic-Velickovic

Ljuba M Mandic

Maria Glibetic

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of the present study was to determine if vitamin D intake and status are associated with pre-eclampsia in a country without a vitamin D fortification policy.

Design: A case-control study of pregnancies with (case) and without (control) pre-eclampsia was conducted from January to April when UVB is minimal. Maternal and cord blood obtained at delivery were measured for plasma 25-hydroxycholecalciferol (25-OH-D3), 3-epimer of 25-OH-D3 (3-epi-25-OH-D3) and 24,25-dihydroxycholecalciferol (24,25-(OH)2D3) by LC-MS/MS and maternal 1,25-dihydroxyvitamin D (1,25-(OH)2D). Differences between groups were tested with ANOVA and Bonferroni post hoc tests (P<0·05).

Setting: Clinical Center of Serbia.

Subjects: Pregnant women with and without pre-eclampsia (n 60) and their infants.

Results: Exogenous vitamin D intake (0·95-16·25 µg/d (38-650 IU/d)) was not significantly different between groups. Women with pre-eclampsia delivered infants at an earlier gestational age and had significantly lower mean total plasma 25-hydroxyvitamin D (25-OH-D; case: 11·2 (sd 5·1); control: 16·1 (sd 5·7) ng/ml; P=0·0006), 25-OH-D3 (case: 10·0 (sd 4·9); control: 14·2 (sd 5·8) ng/ml; P=0·002), 3-epi-25-OH-D3 (case: 0·5 (sd 0·2); control: 0·7 (sd 0·2) ng/ml; P=0·0007) and 1,25-(OH)2D (case: 56·5 (sd 26·6); control: 81·0 (sd 25·7) pg/ml; P=0·018), while 24,25-(OH)2D3 was not different between groups. Infants did not differ in total plasma 25-OH-D, 25-OH-D3, 3-epi-25-OH-D3 and 24,25-(OH)2D3, but the mean proportion of 3-epi-25-OH-D3 was higher in the infant case group (case: 7·9 (sd 1·1); control: 7·0 (sd 1·4) % of total 25-OH-D3; P=0·005).

Conclusions: A high prevalence of vitamin D deficiency, as defined by plasma 25-OH-D<12 ng/ml, was observed in 47 % of all mothers and 77 % of all infants. These data underscore the need for prenatal vitamin D supplementation and a food fortification policy in Serbia.

Citing Articles

Maternal Circulating Vitamin D Level, Targeted Supplementation, and Perinatal Outcomes in Twin Pregnancy.

Roero S, Ingala A, Arduino S, Folino Gallo M, Arese A, Ferrando I Nutrients. 2024; 16(14).

PMID: 39064682 PMC: 11279565. DOI: 10.3390/nu16142239.

Vitamin D and preeclampsia: A systematic review and meta-analysis.

AlSubai A, Baqai M, Agha H, Shankarlal N, Javaid S, Jesrani E SAGE Open Med. 2023; 11:20503121231212093.

PMID: 38020794 PMC: 10666722. DOI: 10.1177/20503121231212093.

Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes.

Karpova N, Dmitrenko O, Arshinova E, Nurbekov M Int J Mol Sci. 2022; 23(21).

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Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths.

Niedermaier T, Gredner T, Kuznia S, Schottker B, Mons U, Lakerveld J Eur J Epidemiol. 2022; 37(4):309-320.

PMID: 35524028 PMC: 9187526. DOI: 10.1007/s10654-022-00867-4.

C3-Epimer of 25-Hydroxyvitamin D3 as a Superior Marker for Predicting the Severity of Chronic Kidney Disease in Rheumatoid Arthritis Patients.

Tang J, Ying B, Yang Y, Xu B, Yu L, Jiang W Oxid Med Cell Longev. 2022; 2022:5268706.

PMID: 35498132 PMC: 9054460. DOI: 10.1155/2022/5268706.

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