Issues for Women with Epilepsy

Overview

Journal Neurol Clin

Specialty Neurology

Date 2016 Apr 19

PMID 27086987

Citations 7

Authors

Naymee J Velez-Ruiz

Page B Pennell

Affiliations

Soon will be listed here.

Abstract

Epilepsy and antiepileptic drugs affect the menstrual cycle, aspects of contraception, reproductive health, pregnancy, and menopause through alteration of sex steroid hormone pathways. Sex steroid hormones often have an effect on seizure frequency and may alter the level of some antiepileptic drugs. Approximately one-third of women experience an increase in perimenstrual and/or periovulatory seizure frequency. Some women experience an increase in seizure frequency during pregnancy. Balancing maternal seizure control and the risk of congenital malformations associated with fetal antiepileptic drug exposure may be challenging. Some antiepileptic drugs are associated with cognitive and behavioral teratogenesis and should be avoided if possible during pregnancy.

Citing Articles

Evaluation of self-stigma in patients with epilepsy: Validation of the self-stigma scale to Spanish (ESSS-S).

Manzanares I, Kuramochi I, Olivera M, Centeno M, Khawaja M, Pintor L Epilepsia Open. 2024; 9(6):2384-2394.

PMID: 39492676 PMC: 11633716. DOI: 10.1002/epi4.13071.

Depot medroxyprogesterone acetate concentrations in patients with and without the use of antiseizure medications.

Dutton C, Mody S, Nippita S, Dodge L, Pang T, Pennell P Contraception. 2024; 134:110418.

PMID: 38452921 PMC: 11340260. DOI: 10.1016/j.contraception.2024.110418.

Hormonal Changes in Women with Epilepsy.

Li Q, Zhang Z, Fang J Neuropsychiatr Dis Treat. 2024; 20:373-388.

PMID: 38436042 PMC: 10906279. DOI: 10.2147/NDT.S453532.

Anti-seizure Medications: Challenges and Opportunities.

Tandon N, Radosavljevic M, Vucevic D, Radenkovic M, Jancic J, Samardzic J CNS Neurol Disord Drug Targets. 2024; 23(9):1120-1133.

PMID: 38192128 DOI: 10.2174/0118715273275793231030060833.

Reversible interventions for menstrual management in adolescents and young adults with gender incongruence.

Roden R Ther Adv Reprod Health. 2023; 17:26334941231158251.

PMID: 36938373 PMC: 10017940. DOI: 10.1177/26334941231158251.

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