Clinical Outcomes in Overweight Heart Transplant Recipients

Overview

Journal Heart Lung

Specialty Cardiology & Vascular Diseases

Date 2016 Apr 19

PMID 27086571

Citations 5

Authors

Anne Jalowiec

Kathleen L Grady

Connie White-Williams

Affiliations

Soon will be listed here.

Abstract

Background: Few studies have examined the impact of patient weight on heart transplant (HT) outcomes.

Objectives: Nine outcomes were compared in 2 groups of HT recipients (N = 347) based on their mean body mass index (BMI) during the first 3 years post-HT.

Methods: Group 1 consisted of 108 non-overweight patients (BMI <25; mean age 52; 29.6% females; 16.7% minorities). Group 2 consisted of 239 overweight patients (BMI ≥25; mean age 52; 15.9% females; 13.8% minorities). Outcomes were: survival, re-hospitalization, rejections, infections, cardiac allograft vasculopathy (CAV), stroke, renal dysfunction, diabetes, and lymphoma.

Results: Non-overweight patients had shorter survival, were re-hospitalized more days after the HT discharge, and had more lymphoma and severe renal dysfunction. Overweight patients had more CAV, steroid-induced diabetes, and acute rejections.

Conclusions: Overweight HT patients had better survival, but more rejections, CAV, and diabetes. Non-overweight HT patients had worse survival, plus more re-hospitalization time, lymphoma, and renal dysfunction.

Citing Articles

Impact of Donor-Recipient BMI Ratio on Survival Outcomes of Heart Transplant Recipients: A Retrospective Analysis Study.

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Cardio-Renal-Metabolic Outcomes Associated With the Use of GLP-1 Receptor Agonists After Heart Transplantation.

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Chen A, Ramirez F, Rosenthal D, Couch S, Berry S, Stauffer K J Am Heart Assoc. 2020; 9(3):e013816.

PMID: 31973598 PMC: 7033874. DOI: 10.1161/JAHA.119.013816.

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