What Do We Know About the Participation of Hematopoietic Stem Cells in Hematopoiesis?

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2016 Apr 16

PMID 27081472

Authors

Nina Drize

Nataliya Petinati

Affiliations

Soon will be listed here.

Abstract

The demonstrated presence in adult tissues of cells with sustained tissue regenerative potential has given rise to the concept of tissue stem cells. Assays to detect and measure such cells indicate that they have enormous proliferative potential and usually an ability to produce all or many of the mature cell types that define the specialized functionality of the tissue. In the hematopoietic system, one or only a few cells can restore lifelong hematopoiesis of the whole organism. To what extent is the maintenance of hematopoietic stem cells required during normal hematopoiesis? How does the constant maintenance of hematopoiesis occur and what is the behavior of the hematopoietic stem cells in the normal organism? How many of the hematopoietic stem cells are created during the development of the organism? How many hematopoietic stem cells are generating more mature progeny at any given moment? What happens to the population of hematopoietic stem cells in aging? This review will attempt to describe the results of recent research which contradict some of the ideas established over the past 30 years about how hematopoiesis is regulated.

References

Siminovitch L, McCulloch E, Till J . THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES. J Cell Comp Physiol. 1963; 62:327-36. DOI: 10.1002/jcp.1030620313. View

Benz C, Copley M, Kent D, Wohrer S, Cortes A, Aghaeepour N . Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell. 2012; 10(3):273-83. DOI: 10.1016/j.stem.2012.02.007. View

Schepers K, Swart E, van Heijst J, Gerlach C, Castrucci M, Sie D . Dissecting T cell lineage relationships by cellular barcoding. J Exp Med. 2008; 205(10):2309-18. PMC: 2556794. DOI: 10.1084/jem.20072462. View

Prchal J, Prchal J, Belickova M, Chen S, Guan Y, Gartland G . Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism. J Exp Med. 1996; 183(2):561-7. PMC: 2192434. DOI: 10.1084/jem.183.2.561. View

Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G . Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med. 2011; 208(13):2691-703. PMC: 3244040. DOI: 10.1084/jem.20111490. View

Medvinsky A, Samoylina N, Muller A, Dzierzak E . An early pre-liver intraembryonic source of CFU-S in the developing mouse. Nature. 1993; 364(6432):64-7. DOI: 10.1038/364064a0. View

Dick J, Magli M, Huszar D, Phillips R, Bernstein A . Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell. 1985; 42(1):71-9. DOI: 10.1016/s0092-8674(85)80102-1. View

Boisset J, Clapes T, Klaus A, Papazian N, Onderwater J, Mommaas-Kienhuis M . Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta. Blood. 2014; 125(3):465-9. PMC: 4296008. DOI: 10.1182/blood-2014-07-588954. View

Rossi D, Jamieson C, Weissman I . Stems cells and the pathways to aging and cancer. Cell. 2008; 132(4):681-96. DOI: 10.1016/j.cell.2008.01.036. View

10.

Kay H . HOW MANY CELL-GENERATIONS?. Lancet. 1965; 2(7409):418-9. DOI: 10.1016/s0140-6736(65)90763-4. View

11.

Medvinsky A, Dzierzak E . Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 1996; 86(6):897-906. DOI: 10.1016/s0092-8674(00)80165-8. View

12.

Fitch S, Kimber G, Wilson N, Parker A, Mirshekar-Syahkal B, Gottgens B . Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Cell Stem Cell. 2012; 11(4):554-66. PMC: 3510442. DOI: 10.1016/j.stem.2012.07.002. View

13.

Moore M, Metcalf D . Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol. 1970; 18(3):279-96. DOI: 10.1111/j.1365-2141.1970.tb01443.x. View

14.

Deichmann A, Hacein-Bey-Abina S, Schmidt M, Garrigue A, Brugman M, Hu J . Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest. 2007; 117(8):2225-32. PMC: 1934585. DOI: 10.1172/JCI31659. View

15.

Trumpp A, Essers M, Wilson A . Awakening dormant haematopoietic stem cells. Nat Rev Immunol. 2010; 10(3):201-9. DOI: 10.1038/nri2726. View

16.

Ivanovs A, Rybtsov S, Welch L, Anderson R, Turner M, Medvinsky A . Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. J Exp Med. 2011; 208(12):2417-27. PMC: 3256972. DOI: 10.1084/jem.20111688. View

17.

Till J, McCulloch E . A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961; 14:213-22. View

18.

Biasco L, Scala S, Basso Ricci L, Dionisio F, Baricordi C, Calabria A . In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells. Sci Transl Med. 2015; 7(273):273ra13. DOI: 10.1126/scitranslmed.3010314. View

19.

Drize N, Keller J, Chertkov J . Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice. Blood. 1996; 88(8):2927-38. View

20.

Wilson A, Laurenti E, Oser G, van der Wath R, Blanco-Bose W, Jaworski M . Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008; 135(6):1118-29. DOI: 10.1016/j.cell.2008.10.048. View