MiR-196, an Emerging Cancer Biomarker for Digestive Tract Cancers

Overview

Journal J Cancer

Specialty Oncology

Date 2016 Apr 15

PMID 27076845

Citations 32

Authors

Ya-Ching Lu

Joseph T Chang

Err-Cheng Chan

Yin-Kai Chao

Ta-Sen Yeh

Jinn-Shiun Chen

Ann-Joy Cheng

Affiliations

Soon will be listed here.

Abstract

Over the past decade, the emergence of microRNA (miRNA) research has firmly established this molecular family as a key component in cells. MiRNAs, which function as negative gene regulators, participate in multiple biological processes and maintain homeostasis in cells. The dysregulation of miRNA may contribute to numerous human disorders, including cancer. Recently, miR-196 was found to be aberrantly expressed in a wide range of malignant diseases, which suggests that it plays important roles in carcinogenesis. Here, we summarize the current knowledge concerning miR-196 family in cancers. This review includes miR-196 gene structure and aberrant expression in various cancers, and current understanding of numerous functions and regulatory targets of miR-196 in specific cancers. Since miR-196 are consistently found over-expressed in digestive tract cancer tissues, we also reviewed the clinical significance and potential applications of miR-196 in these cancers. We highlight that miR-196 may serve as an emerging cancer biomarker for digestive tract cancers.

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