Synaptic Mechanisms of Memory Consolidation During Sleep Slow Oscillations

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Apr 15

PMID 27076422

Citations 42

Authors

Yina Wei

Giri P Krishnan

Maxim Bazhenov

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Sleep is critical for memory and learning. Replay during sleep of temporally ordered spike sequences related to a recent experience was proposed to be a neuronal substrate of memory consolidation. However, specific mechanisms of replay or how spike sequence replay leads to synaptic changes that underlie memory consolidation are still poorly understood. Here we used a detailed computational model of the thalamocortical system to report that interaction between slow cortical oscillations and synaptic plasticity during deep sleep can underlie mapping hippocampal memory traces to persistent cortical representation. This study provided, for the first time, a mechanistic explanation of how slow-wave sleep may promote consolidation of recent memory events.

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