The Impact of Serum Uric Acid on the Natural History of Glomerular Filtration Rate: a Retrospective Study in the General Population

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2016 Apr 13

PMID 27069799

Citations 6

Authors

Ying Xu

Xiang Liu

Xiaohe Sun

Yibing Wang

Affiliations

Soon will be listed here.

Abstract

Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the association of the SUA level with the GFR decline in a general population. Two thousand, seven hundred and eighty-nine subjects who visited the Health Checkup Clinic both at 2008 and 2013 were identified. A significant inverse correlation was observed between change in SUA from 2008-2013 (ΔSUA) and change in eGFR (ΔeGFR) during the same period. Multivariate regression analysis of ΔeGFR indicated that the increase in SUA over time were a negative predictor of the change in eGFR. Our result indicates that the decline of eGFR over years is larger in subjects with an increased SUA level, which helps to underline the importance of SUA level management in the context of kidney function preservation.

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