Blood Triacylglycerols: a Lipidomic Window on Diet and Disease

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2016 Apr 13

PMID 27068982

Citations 12

Authors

Francis Sanders

Ben McNally

Julian L Griffin

Affiliations

Soon will be listed here.

Abstract

Although the measurement of triacylglycerols (TAGs) by clinical chemistry has been used in the diagnosis of a range of metabolic diseases, such approaches ignore the different species of TAGs that contribute to the total concentration. With the advent of LC and direct infusion forms of MS it is now possible to profile the individual TAGs in blood plasma or tissue extracts. This mini review surveys the information that is obtainable from the lipidomic profiling of TAGs in following metabolic diseases such as type 2 diabetes (T2DM), cardiovascular disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity.

Citing Articles

Skin Metabolic Signatures of Psoriasis and Psoriasis Concurrent with Metabolic Syndrome.

Yan L, Wang W, Dong M, Wang R, Li C J Inflamm Res. 2025; 18():505-517.

PMID: 39810975 PMC: 11730757. DOI: 10.2147/JIR.S493338.

Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes.

Duft R, Bonfante I, Palma-Duran S, Chacon-Mikahil M, Griffin J, Cavaglieri C J Clin Endocrinol Metab. 2024; 109(9):2182-2198.

PMID: 38488044 PMC: 11318996. DOI: 10.1210/clinem/dgae177.

Omics to Unveil Diabetes Mellitus Pathogenesis and Biomarkers: Focus on Proteomics, Lipidomics, and Metabolomics.

Soares N, Magalhaes G, Mayrink P, Verano-Braga T Adv Exp Med Biol. 2024; 1443:211-220.

PMID: 38409423 DOI: 10.1007/978-3-031-50624-6_11.

Integrated multi-omics and machine learning approach reveals lipid metabolic biomarkers and signaling in age-related meibomian gland dysfunction.

Cai Y, Zhang S, Chen L, Fu Y Comput Struct Biotechnol J. 2023; 21:4215-4227.

PMID: 37675286 PMC: 10480060. DOI: 10.1016/j.csbj.2023.08.026.

Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study.

Monfort-Pires M, Lamichhane S, Alonso C, Egelandsdal B, Oresic M, Jordahl V Int J Mol Sci. 2023; 24(5).

PMID: 36902372 PMC: 10003363. DOI: 10.3390/ijms24054941.