Myeloid-Derived Suppressor Cells in Bacterial Infections

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2016 Apr 12

PMID 27066459

Citations 67

Authors

Michael Ost

Anurag Singh

Andreas Peschel

Roman Mehling

Nikolaus Rieber

Dominik Hartl

Affiliations

Soon will be listed here.

Abstract

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

Citing Articles

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