Cachexia in Chronic Obstructive Pulmonary Disease: New Insights and Therapeutic Perspective

Overview

Journal J Cachexia Sarcopenia Muscle

Date 2016 Apr 12

PMID 27066314

Citations 63

Authors

Karin J C Sanders

Anita E M Kneppers

Coby van de Bool

Ramon C J Langen

Annemie M W J Schols

Affiliations

Soon will be listed here.

Abstract

Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD-induced cachexia.

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