Semaphorin 7a Exerts Pleiotropic Effects to Promote Breast Tumor Progression

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2016 Apr 12

PMID 27065336

Citations 36

Authors

S A Black

A C Nelson

N J Gurule

B W Futscher

T R Lyons

Affiliations

Soon will be listed here.

Abstract

Understanding what drives breast tumor progression is of utmost importance for blocking tumor metastasis; we have identified that semaphorin 7a is a potent driver of ductal carcinoma in situ (DCIS) progression. Semaphorin 7a is a glycophosphatidylinositol membrane-anchored protein that promotes attachment and spreading in multiple cell types. Here, we show that increased expression of SEMA7A occurs in a large percentage of breast cancers and is associated with decreased overall and distant metastasis-free survival. In both in vitro and in vivo models, short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of β1-integrin receptor. Our results suggest that semaphorin 7a may be novel target for blocking breast tumor progression.

Citing Articles

Pan-Cancer Analysis of the Prognostic and Immunological Role of SEMA7A.

Yang L, Zhang S, Zheng L, Kong F, Dang W, Shen S Int J Gen Med. 2024; 17:6443-6461.

PMID: 39735166 PMC: 11682669. DOI: 10.2147/IJGM.S499872.

SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front.

Chen Y, Tien S, Ko Y, Chang C, Hsu M, Chien H Cancer Gene Ther. 2024; 31(12):1840-1855.

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Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal Cancer Tissue.

Ochman B, Limanowka P, Mielcarska S, Kula A, Dawidowicz M, Wagner W Curr Issues Mol Biol. 2024; 46(9):10218-10248.

PMID: 39329961 PMC: 11431007. DOI: 10.3390/cimb46090609.

SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer.

Zhang S, Kong F, Zheng L, Li X, Jia L, Yang L Int J Gen Med. 2024; 17:4081-4099.

PMID: 39295856 PMC: 11410036. DOI: 10.2147/IJGM.S474827.

Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance.

Aiyappa-Maudsley R, McLoughlin L, Hughes T Int J Mol Sci. 2023; 24(17).

PMID: 37685898 PMC: 10487980. DOI: 10.3390/ijms241713093.

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