Molecular and Cellular Neurocardiology: Development, and Cellular and Molecular Adaptations to Heart Disease

Overview

Journal J Physiol

Specialty Physiology

Date 2016 Apr 10

PMID 27060296

Citations 53

Authors

Beth A Habecker

Mark E Anderson

Susan J Birren

Keiichi Fukuda

Neil Herring

Donald B Hoover

Hideaki Kanazawa

David J Paterson

Crystal M Ripplinger

Affiliations

Soon will be listed here.

Abstract

The nervous system and cardiovascular system develop in concert and are functionally interconnected in both health and disease. This white paper focuses on the cellular and molecular mechanisms that underlie neural-cardiac interactions during development, during normal physiological function in the mature system, and during pathological remodelling in cardiovascular disease. The content on each subject was contributed by experts, and we hope that this will provide a useful resource for newcomers to neurocardiology as well as aficionados.

Citing Articles

The Brain-Heart Network of Syncope.

Barik S, Riddell T Int J Mol Sci. 2024; 25(13).

PMID: 39000068 PMC: 11241714. DOI: 10.3390/ijms25136959.

Molecular and cellular neurocardiology in heart disease.

Habecker B, Bers D, Birren S, Chang R, Herring N, Kay M J Physiol. 2024; .

PMID: 38778747 PMC: 11582088. DOI: 10.1113/JP284739.

Exploring the prospects, advancements, and challenges of modeling of the heart-brain axis.

Mabry S, Pavon N Front Cell Neurosci. 2024; 18:1386355.

PMID: 38766369 PMC: 11099243. DOI: 10.3389/fncel.2024.1386355.

The Intrinsic Cardiac Nervous System: From Pathophysiology to Therapeutic Implications.

Giannino G, Braia V, Griffith Brookles C, Giacobbe F, DAscenzo F, Angelini F Biology (Basel). 2024; 13(2).

PMID: 38392323 PMC: 10887082. DOI: 10.3390/biology13020105.

Sympathetic remodeling and altered angiotensin-converting enzyme 2 localization occur in patients with cardiac disease but are not exacerbated by severe COVID-19.

Kellum C, Kirkland L, Nelson T, Jewett S, Rytkin E, Efimov I Auton Neurosci. 2023; 251:103134.

PMID: 38101169 PMC: 10872860. DOI: 10.1016/j.autneu.2023.103134.

References

Moon J, Birren S . Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway. Dev Biol. 2008; 315(2):404-17. PMC: 2287379. DOI: 10.1016/j.ydbio.2007.12.041. View

Saito K, Gutkind J, Saavedra J . Angiotensin II binding sites in the conduction system of rat hearts. Am J Physiol. 1987; 253(6 Pt 2):H1618-22. DOI: 10.1152/ajpheart.1987.253.6.H1618. View

Hoard J, Hoover D, Mabe A, Blakely R, Feng N, Paolocci N . Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience. 2008; 156(1):129-42. PMC: 2640831. DOI: 10.1016/j.neuroscience.2008.06.063. View

Yoon M, Han J, Tse W, Rogers R . Effects of vagal stimulation, atropine, and propranolol on fibrillation threshold of normal and ischemic ventricles. Am Heart J. 1977; 93(1):60-5. DOI: 10.1016/s0002-8703(77)80172-5. View

Marx S, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N . PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000; 101(4):365-76. DOI: 10.1016/s0092-8674(00)80847-8. View

Cao J, Chen L, KenKnight B, Ohara T, Lee M, Tsai J . Nerve sprouting and sudden cardiac death. Circ Res. 2000; 86(7):816-21. DOI: 10.1161/01.res.86.7.816. View

Lefkowitz R, Rockman H, Koch W . Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation. 2000; 101(14):1634-7. DOI: 10.1161/01.cir.101.14.1634. View

OConnor C, Starling R, Hernandez A, Armstrong P, Dickstein K, Hasselblad V . Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011; 365(1):32-43. DOI: 10.1056/NEJMoa1100171. View

Thayer J, Lane R . The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol. 2006; 74(2):224-42. DOI: 10.1016/j.biopsycho.2005.11.013. View

10.

Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M . Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nat Med. 2007; 13(5):604-12. DOI: 10.1038/nm1570. View

11.

Lu C, Hao G, Nikiforova N, Larsen H, Liu K, Crabtree M . CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. Hypertension. 2015; 65(6):1288-1297. PMC: 4487208. DOI: 10.1161/HYPERTENSIONAHA.115.05290. View

12.

He B, Joiner M, Singh M, Luczak E, Swaminathan P, Koval O . Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med. 2011; 17(12):1610-8. PMC: 3332099. DOI: 10.1038/nm.2506. View

13.

Hogan K, Markos F . Vasoactive intestinal polypeptide receptor antagonism enhances the vagally induced increase in cardiac interval of the rat atrium in vitro. Exp Physiol. 2006; 91(3):641-6. DOI: 10.1113/expphysiol.2006.033605. View

14.

Valdivia H, Kaplan J, Lederer W . Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science. 1995; 267(5206):1997-2000. PMC: 4242209. DOI: 10.1126/science.7701323. View

15.

Nabauer M, Beuckelmann D, Uberfuhr P, Steinbeck G . Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 1996; 93(1):168-77. DOI: 10.1161/01.cir.93.1.168. View

16.

Esler M, Kaye D, Lambert G, Esler D, Jennings G . Adrenergic nervous system in heart failure. Am J Cardiol. 1997; 80(11A):7L-14L. DOI: 10.1016/s0002-9149(97)00844-8. View

17.

Swaminathan P, Purohit A, Soni S, Voigt N, Singh M, Glukhov A . Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011; 121(8):3277-88. PMC: 3223923. DOI: 10.1172/JCI57833. View

18.

Vaseghi M, Gima J, Kanaan C, Ajijola O, Marmureanu A, Mahajan A . Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up. Heart Rhythm. 2013; 11(3):360-6. PMC: 4253031. DOI: 10.1016/j.hrthm.2013.11.028. View

19.

Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens X . Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014; 107(12):2815-2827. PMC: 4269787. DOI: 10.1016/j.bpj.2014.10.054. View

20.

Wu Y, Gao Z, Chen B, Koval O, Singh M, Guan X . Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009; 106(14):5972-7. PMC: 2667018. DOI: 10.1073/pnas.0806422106. View