Understanding the CREB1-miRNA Feedback Loop in Human Malignancies

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Apr 10

PMID 27059735

Citations 23

Authors

Ya-Wen Wang

Xu Chen

Rong Ma

Peng Gao

Affiliations

Soon will be listed here.

Abstract

cAMP response element binding protein 1 (CREB1, CREB) is a key transcription factor that mediates transcriptional responses to a variety of growth factors and stress signals. CREB1 has been shown to play a critical role in development and progression of tumors. MicroRNAs (miRNAs) are a class of non-coding RNAs. They post-transcriptionally regulate gene expression through pairing with the 3'-UTR of their target mRNAs and thus regulate initiation and progression of various types of human cancers. Recent studies have demonstrated that a number of miRNAs can be transcriptionally regulated by CREB1. Interestingly, CREB1 expression can also be modulated by miRNAs, thus forming a feedback loop. This review outlines the functional roles of CREB1, miRNA, and their interactions in human malignancies. This will help to define a relationship between CREB1 and miRNA in human cancer and develop novel therapeutic strategies.

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