Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2016 Apr 9

PMID 27056543

Citations 116

Authors

FuiBoon Kai

Hanane Laklai

Valerie M Weaver

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.

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