Brain-Wide Maps of Synaptic Input to Cortical Interneurons

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Apr 8

PMID 27053207

Citations 88

Authors

Nicholas R Wall

Mauricio De La Parra

Jordan M Sorokin

Hiroki Taniguchi

Z Josh Huang

Edward M Callaway

Affiliations

Soon will be listed here.

Abstract

Significance Statement: These results indicate that all three major interneuron classes in the barrel cortex integrate both feedforward and feedback information from throughout the brain to modulate the activity of the local cortical circuit. However, differences in laminar sources and magnitude of distant cortical input suggest differential contributions from cortical areas. More input to vasoactive intestinal peptide-positive (VIP+) neurons than to somatostatin-positive (SST+) neurons suggests that disinhibition of the cortex via VIP+ cells, which inhibit SST+ cells, might be a general feature of long-distance corticocortical and thalamocortical circuits.

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