Cancer and Non-cancer Mortality Among French Uranium Cycle Workers: the TRACY Cohort

Overview

Journal BMJ Open

Specialty General Medicine

Date 2016 Apr 7

PMID 27048635

Citations 11

Authors

Eric Samson

Irwin Piot

Sergey Zhivin

David B Richardson

Pierre Laroche

Ana-Paula Serond

Dominique Laurier

Olivier Laurent

Affiliations

Soon will be listed here.

Abstract

Objectives: The health effects of internal contamination by radionuclides, and notably by uranium, are poorly characterised. New cohorts of uranium workers are needed to better examine these effects. This paper analyses for the first time the mortality profile of the French cohort of uranium cycle workers. It considers mortality from cancer and non-cancer causes.

Methods: The cohort includes workers employed at least 6 months between 1958 and 2006 in French companies involved in the production of nuclear fuel. Vital status and causes of death were collected from French national registries. Workers were followed-up from 1 January 1968 to 31 December 2008. Standardised mortality ratios (SMRs) were computed based on mortality rates for the French general population.

Results: The cohort includes 12,649 workers (88% men). The average length of follow-up is 27 years and the mean age at the end of the study is 60 years. Large mortality deficits are observed for non-cancer causes of death such as non-cancer respiratory diseases (SMR=0.51 (0.41 to 0.63)) and circulatory diseases (SMR=0.68 (0.62 to 0.74)). A mortality deficit of lower magnitude is also observed for all cancers combined (SMR (95% CI): 0.76 (0.71 to 0.81)). Pleural mesothelioma is elevated (SMR=2.04 (1.19 to 3.27)).

Conclusions: A healthy worker effect is observed in this new cohort of workers involved in the uranium cycle. Collection of individual information on internal uranium exposure as well as other risk factors is underway, to allow for the investigation of uranium-related risks.

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References

Chan C, Hughes T, Muldoon S, Aldrich T, Rice C, Hornung R . Mortality patterns among Paducah Gaseous Diffusion Plant workers. J Occup Environ Med. 2010; 52(7):725-32. PMC: 2983475. DOI: 10.1097/JOM.0b013e3181e48ee0. View

Pinheiro G, Antao V, Bang K, Attfield M . Malignant mesothelioma surveillance: a comparison of ICD 10 mortality data with SEER incidence data in nine areas of the United States. Int J Occup Environ Health. 2004; 10(3):251-5. DOI: 10.1179/oeh.2004.10.3.251. View

Vrijheid M, Cardis E, Blettner M, Gilbert E, Hakama M, Hill C . The 15-Country Collaborative Study of Cancer Risk Among Radiation Workers in the Nuclear Industry: design, epidemiological methods and descriptive results. Radiat Res. 2007; 167(4):361-79. DOI: 10.1667/RR0554.1. View

Baillargeon J . Characteristics of the healthy worker effect. Occup Med. 2001; 16(2):359-66. View

Metz-Flamant C, Guseva Canu I, Laurier D . Malignant pleural mesothelioma risk among nuclear workers: a review. J Radiol Prot. 2011; 31(1):9-23. DOI: 10.1088/0952-4746/31/1/R01. View

Zablotska L, Lane R, Frost S . Mortality (1950-1999) and cancer incidence (1969-1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses. BMJ Open. 2013; 3(2). PMC: 3586082. DOI: 10.1136/bmjopen-2012-002159. View

McGeoghegan D, Binks K . The mortality and cancer morbidity experience of workers at the Springfields uranium production facility, 1946-95. J Radiol Prot. 2000; 20(2):111-37. DOI: 10.1088/0952-4746/20/2/301. View

Dinocourt C, Legrand M, Dublineau I, Lestaevel P . The neurotoxicology of uranium. Toxicology. 2015; 337:58-71. DOI: 10.1016/j.tox.2015.08.004. View

Zhivin S, Laurier D, Guseva Canu I . Health effects of occupational exposure to uranium: do physicochemical properties matter?. Int J Radiat Biol. 2014; 90(11):1104-13. DOI: 10.3109/09553002.2014.943849. View

10.

Kreuzer M, Dufey F, Laurier D, Nowak D, Marsh J, Schnelzer M . Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946-2008. Int Arch Occup Environ Health. 2014; 88(4):431-41. DOI: 10.1007/s00420-014-0973-2. View

11.

Richardson D, Keil A, Tchetgen Tchetgen E, Cooper G . Negative Control Outcomes and the Analysis of Standardized Mortality Ratios. Epidemiology. 2015; 26(5):727-32. PMC: 4763995. DOI: 10.1097/EDE.0000000000000353. View

12.

Lestaevel P, Houpert P, Bussy C, Dhieux B, Gourmelon P, Paquet F . The brain is a target organ after acute exposure to depleted uranium. Toxicology. 2005; 212(2-3):219-26. DOI: 10.1016/j.tox.2005.05.002. View

13.

Gilbert E, Sokolnikov M, Preston D, Schonfeld S, Schadilov A, Vasilenko E . Lung cancer risks from plutonium: an updated analysis of data from the Mayak worker cohort. Radiat Res. 2013; 179(3):332-42. PMC: 3661277. DOI: 10.1667/RR3054.1. View

14.

Boice Jr J, Cohen S, Mumma M, Chadda B, Blot W . A cohort study of uranium millers and miners of Grants, New Mexico, 1979-2005. J Radiol Prot. 2008; 28(3):303-25. DOI: 10.1088/0952-4746/28/3/002. View

15.

Pinkerton L, Bloom T, Hein M, Ward E . Mortality among a cohort of uranium mill workers: an update. Occup Environ Med. 2003; 61(1):57-64. PMC: 1757824. View

16.

Rage E, Caer-Lorho S, Drubay D, Ancelet S, Laroche P, Laurier D . Mortality analyses in the updated French cohort of uranium miners (1946-2007). Int Arch Occup Environ Health. 2014; 88(6):717-30. DOI: 10.1007/s00420-014-0998-6. View

17.

McGeoghegan D, Binks K . The mortality and cancer morbidity experience of workers at the Capenhurst uranium enrichment facility 1946-95. J Radiol Prot. 2001; 20(4):381-401. DOI: 10.1088/0952-4746/20/4/303. View

18.

Metz-Flamant C, Laurent O, Samson E, Caer-Lorho S, Acker A, Hubert D . Mortality associated with chronic external radiation exposure in the French combined cohort of nuclear workers. Occup Environ Med. 2013; 70(9):630-8. DOI: 10.1136/oemed-2012-101149. View

19.

Shaki F, Hosseini M, Ghazi-Khansari M, Pourahmad J . Depleted uranium induces disruption of energy homeostasis and oxidative stress in isolated rat brain mitochondria. Metallomics. 2013; 5(6):736-44. DOI: 10.1039/c3mt00019b. View

20.

Boice J, Cohen S, Mumma M, Ellis E, Eckerman K, Leggett R . Mortality among radiation workers at Rocketdyne (Atomics International), 1948-1999. Radiat Res. 2006; 166(1 Pt 1):98-115. DOI: 10.1667/RR3582.1. View