Subgenual Cingulum Microstructure Supports Control of Emotional Conflict

Overview

Journal Cereb Cortex

Publisher Oxford University Press

Specialty Neurology

Date 2016 Apr 7

PMID 27048427

Citations 14

Authors

Paul A Keedwell

Amie N Doidge

Marcel Meyer

Natalia Lawrence

Andrew D Lawrence

Derek K Jones

Affiliations

Soon will be listed here.

Abstract

Major depressive disorder (MDD) is associated with specific difficulties in attentional disengagement from negatively valenced material. Diffusion MRI studies have demonstrated altered white matter microstructure in the subgenual cingulum bundle (CB) in individuals with MDD, though the functional significance of these alterations has not been examined formally. This study explored whether individual differences in selective attention to negatively valenced stimuli are related to interindividual differences in subgenual CB microstructure. Forty-six individuals (21 with remitted MDD, 25 never depressed) completed an emotional Stroop task, using happy and angry distractor faces overlaid by pleasant or unpleasant target words and a control gender-based Stroop task. CBs were reconstructed in 38 individuals using diffusion-weighted imaging and tractography, and mean fractional anisotropy (FA) computed for the subgenual, retrosplenial, and parahippocampal subdivisions. No significant correlations were found between FA and performance in the control gender-based Stroop task in any CB region. However, the degree of interference produced by angry face distractors on time to identify pleasant words (emotional conflict) correlated selectively with FA in the subgenual CB (r = -0.53; P = 0.01). Higher FA was associated with reduced interference, irrespective of a diagnosis of MDD, suggesting that subgenual CB microstructure is functionally relevant for regulating attentional bias toward negative interpersonal stimuli.

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References

Buckholtz J, Meyer-Lindenberg A . Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. Neuron. 2012; 74(6):990-1004. DOI: 10.1016/j.neuron.2012.06.002. View

Epp A, Dobson K, Dozois D, Frewen P . A systematic meta-analysis of the Stroop task in depression. Clin Psychol Rev. 2012; 32(4):316-28. DOI: 10.1016/j.cpr.2012.02.005. View

Foland-Ross L, Gotlib I . Cognitive and neural aspects of information processing in major depressive disorder: an integrative perspective. Front Psychol. 2012; 3:489. PMC: 3495336. DOI: 10.3389/fpsyg.2012.00489. View

Huang H, Fan X, Williamson D, Rao U . White matter changes in healthy adolescents at familial risk for unipolar depression: a diffusion tensor imaging study. Neuropsychopharmacology. 2010; 36(3):684-91. PMC: 3036948. DOI: 10.1038/npp.2010.199. View

Wright D, Sladden B . An own gender bias and the importance of hair in face recognition. Acta Psychol (Amst). 2003; 114(1):101-14. DOI: 10.1016/s0001-6918(03)00052-0. View

Bracht T, Doidge A, Keedwell P, Jones D . Hedonic tone is associated with left supero-lateral medial forebrain bundle microstructure. Psychol Med. 2014; 45(4):865-74. PMC: 4413785. DOI: 10.1017/S0033291714001949. View

Jones D, Travis A, Eden G, Pierpaoli C, Basser P . PASTA: pointwise assessment of streamline tractography attributes. Magn Reson Med. 2005; 53(6):1462-7. DOI: 10.1002/mrm.20484. View

Cullen K, Klimes-Dougan B, Muetzel R, Mueller B, Camchong J, Houri A . Altered white matter microstructure in adolescents with major depression: a preliminary study. J Am Acad Child Adolesc Psychiatry. 2010; 49(2):173-83.e1. PMC: 2909686. DOI: 10.1097/00004583-201002000-00011. View

Etkin A, Egner T, Peraza D, Kandel E, Hirsch J . Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron. 2006; 51(6):871-82. DOI: 10.1016/j.neuron.2006.07.029. View

10.

Carlson J, Cha J, Harmon-Jones E, Mujica-Parodi L, Hajcak G . Influence of the BDNF genotype on amygdalo-prefrontal white matter microstructure is linked to nonconscious attention bias to threat. Cereb Cortex. 2013; 24(9):2249-57. DOI: 10.1093/cercor/bht089. View

11.

Wetzels R, Wagenmakers E . A default Bayesian hypothesis test for correlations and partial correlations. Psychon Bull Rev. 2012; 19(6):1057-64. PMC: 3505519. DOI: 10.3758/s13423-012-0295-x. View

12.

Offringa R, Handwerger Brohawn K, Staples L, Dubois S, Hughes K, Pfaff D . Diminished rostral anterior cingulate cortex activation during trauma-unrelated emotional interference in PTSD. Biol Mood Anxiety Disord. 2013; 3(1):10. PMC: 3668994. DOI: 10.1186/2045-5380-3-10. View

13.

Maeshima H, Baba H, Nakano Y, Satomura E, Namekawa Y, Takebayashi N . Residual memory dysfunction in recurrent major depressive disorder--a longitudinal study from Juntendo University Mood Disorder Project. J Affect Disord. 2012; 143(1-3):84-8. DOI: 10.1016/j.jad.2012.05.033. View

14.

Vokey J, Read J . Typicality, familiarity and the recognition of male and female faces. Can J Psychol. 1988; 42(4):489-95. DOI: 10.1037/h0084202. View

15.

Demeyer I, De Lissnyder E, Koster E, De Raedt R . Rumination mediates the relationship between impaired cognitive control for emotional information and depressive symptoms: A prospective study in remitted depressed adults. Behav Res Ther. 2012; 50(5):292-7. DOI: 10.1016/j.brat.2012.02.012. View

16.

Bishop S, Duncan J, Brett M, Lawrence A . Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli. Nat Neurosci. 2004; 7(2):184-8. DOI: 10.1038/nn1173. View

17.

Leemans A, Jones D . The B-matrix must be rotated when correcting for subject motion in DTI data. Magn Reson Med. 2009; 61(6):1336-49. DOI: 10.1002/mrm.21890. View

18.

Gotlib I, Krasnoperova E, Yue D, Joormann J . Attentional biases for negative interpersonal stimuli in clinical depression. J Abnorm Psychol. 2004; 113(1):121-35. DOI: 10.1037/0021-843X.113.1.121. View

19.

Metzler-Baddeley C, Jones D, Steventon J, Westacott L, Aggleton J, OSullivan M . Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. J Neurosci. 2012; 32(49):17612-9. PMC: 6621654. DOI: 10.1523/JNEUROSCI.3299-12.2012. View

20.

Donegan N, Sanislow C, Blumberg H, Fulbright R, Lacadie C, Skudlarski P . Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biol Psychiatry. 2003; 54(11):1284-93. DOI: 10.1016/s0006-3223(03)00636-x. View