Pharmacologic Treatment of Pediatric Hypertension

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2016 Apr 7

PMID 27048353

Citations 4

Authors

Rachita S Dhull

Rossana Baracco

Amrish Jain

Tej K Mattoo

Affiliations

Soon will be listed here.

Abstract

Prevalence of hypertension is increasing in children and adolescents. Uncontrolled hypertension in children not only causes end organ damage but also increases the risk of adult hypertension and cardiovascular disease. Clinical trials have proven efficacy of antihypertensive medications in children. These medications are well tolerated by children with acceptable safety profile. The choice of agent is usually driven by underlying etiology of hypertension, profile of its side effects, and clinician's preference. This article will review currently available pediatric data on mechanism of action, common adverse effects, pediatric indication, recent clinical trial, and newer drugs in the common classes of antihypertensive medications.

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References

Blowey D . Safety of the newer antihypertensive agents in children. Expert Opin Drug Saf. 2003; 1(1):39-43. DOI: 10.1517/14740338.1.1.39. View

Webb N, Lam C, Loeys T, Shahinfar S, Strehlau J, Wells T . Randomized, double-blind, controlled study of losartan in children with proteinuria. Clin J Am Soc Nephrol. 2010; 5(3):417-24. PMC: 2827569. DOI: 10.2215/CJN.06620909. View

Hazan L, Hernandez Rodriguez O, Bhorat A, Miyazaki K, Tao B, Heyrman R . A double-blind, dose-response study of the efficacy and safety of olmesartan medoxomil in children and adolescents with hypertension. Hypertension. 2010; 55(6):1323-30. DOI: 10.1161/HYPERTENSIONAHA.109.147702. View

Wuhl E, Trivelli A, Picca S, Litwin M, Peco-Antic A, Zurowska A . Strict blood-pressure control and progression of renal failure in children. N Engl J Med. 2009; 361(17):1639-50. DOI: 10.1056/NEJMoa0902066. View

Menon S, Berezny K, Kilaru R, Benjamin Jr D, Kay J, Hazan L . Racial differences are seen in blood pressure response to fosinopril in hypertensive children. Am Heart J. 2006; 152(2):394-9. DOI: 10.1016/j.ahj.2005.12.025. View

Shahinfar S, Cano F, Soffer B, Ahmed T, Santoro E, Zhang Z . A double-blind, dose-response study of losartan in hypertensive children. Am J Hypertens. 2005; 18(2 Pt 1):183-90. DOI: 10.1016/j.amjhyper.2004.09.009. View

Falkner B . Hypertension in children and adolescents: epidemiology and natural history. Pediatr Nephrol. 2009; 25(7):1219-24. PMC: 2874036. DOI: 10.1007/s00467-009-1200-3. View

Li J, Berezny K, Kilaru R, Hazan L, Portman R, Hogg R . Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?. Hypertension. 2004; 44(3):289-93. DOI: 10.1161/01.HYP.0000138069.68413.f0. View

Baker-Smith C, Benjamin Jr D, Califf R, Murphy M, Li J, Smith P . Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials. Clin Pharmacol Ther. 2010; 87(6):668-71. PMC: 2874085. DOI: 10.1038/clpt.2009.231. View

10.

Silverstein D, Palmer J, Baluarte H, Brass C, Conley S, Polinsky M . Use of calcium-channel blockers in pediatric renal transplant recipients. Pediatr Transplant. 1999; 3(4):288-92. DOI: 10.1034/j.1399-3046.1999.00056.x. View

11.

Flynn J, Newburger J, Daniels S, Sanders S, Portman R, Hogg R . A randomized, placebo-controlled trial of amlodipine in children with hypertension. J Pediatr. 2004; 145(3):353-9. DOI: 10.1016/j.jpeds.2004.04.009. View

12.

. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004; 114(2 Suppl 4th Report):555-76. View

13.

Juhola J, Magnussen C, Berenson G, Venn A, Burns T, Sabin M . Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the International Childhood Cardiovascular Cohort Consortium. Circulation. 2013; 128(3):217-24. PMC: 3875837. DOI: 10.1161/CIRCULATIONAHA.113.001614. View

14.

Li J, Flynn J, Portman R, Davis I, Ogawa M, Shi H . The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study. J Pediatr. 2010; 157(2):282-7. DOI: 10.1016/j.jpeds.2010.02.042. View

15.

Petrie M, PADMANABHAN N, McDonald J, Hillier C, Connell J, McMurray J . Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease. J Am Coll Cardiol. 2001; 37(4):1056-61. DOI: 10.1016/s0735-1097(01)01111-1. View

16.

Trachtman H . Short- and long-term physiologic and pharmacologic control of blood pressure in pediatric patients. Integr Blood Press Control. 2011; 4:35-44. PMC: 3172076. DOI: 10.2147/IBPC.S17265. View

17.

Soffer B, Zhang Z, Miller K, Vogt B, Shahinfar S . A double-blind, placebo-controlled, dose-response study of the effectiveness and safety of lisinopril for children with hypertension. Am J Hypertens. 2003; 16(10):795-800. DOI: 10.1016/s0895-7061(03)00900-2. View

18.

Gradman A, Schmieder R, Lins R, Nussberger J, Chiang Y, Bedigian M . Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation. 2005; 111(8):1012-8. DOI: 10.1161/01.CIR.0000156466.02908.ED. View

19.

Batisky D, Sorof J, Sugg J, Llewellyn M, Klibaner M, Hainer J . Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience. J Pediatr. 2007; 150(2):134-9, 139.e1. DOI: 10.1016/j.jpeds.2006.09.034. View

20.

Romero M, Kapur G, Baracco R, Valentini R, Mattoo T, Jain A . Treatment of Hypertension in Children With Catecholamine-Secreting Tumors: A Systematic Approach. J Clin Hypertens (Greenwich). 2015; 17(9):720-5. PMC: 8031986. DOI: 10.1111/jch.12571. View