NELL-1 Expression in Tumors of Cartilage

Overview

Journal J Orthop

Specialty Orthopedics

Date 2016 Apr 6

PMID 27047227

Citations 7

Authors

Jia Shen

Gregory LaChaud

Swati Shrestha

Greg Asatrian

Xinli Zhang

Sarah M Dry

Chia Soo

Kang Ting

Aaron W James

Affiliations

Soon will be listed here.

Abstract

Background/aims: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.

Methods: Immunohistochemical expression was examined in human pathologic specimens.

Results: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.

Conclusion: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

Citing Articles

Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).

Li Z, Tian Y Int J Mol Med. 2024; 55(1).

PMID: 39450541 PMC: 11537270. DOI: 10.3892/ijmm.2024.5446.

Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2.

Pan R, Lu Q, Ren C, Li H, Zeng F, Tian X Aging (Albany NY). 2021; 13(13):17316-17327.

PMID: 34238763 PMC: 8312408. DOI: 10.18632/aging.203212.

Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and Beyond.

Li C, Zhang X, Zheng Z, Nguyen A, Ting K, Soo C J Dent Res. 2019; 98(13):1458-1468.

PMID: 31610747 PMC: 6873286. DOI: 10.1177/0022034519882000.

Age dependent effects of NELL-1 isoforms on bone marrow stromal cells.

Meyers C, Sun Z, Chang L, Ding C, Lu A, Ting K J Orthop. 2019; 16(2):175-178.

PMID: 30899146 PMC: 6406628. DOI: 10.1016/j.jor.2019.02.006.

Biomarkers of chondrosarcoma.

Jeong W, Kim H J Clin Pathol. 2018; 71(7):579-583.

PMID: 29593061 PMC: 6204964. DOI: 10.1136/jclinpath-2018-205071.

References

Ting K, Vastardis H, Mulliken J, Soo C, Tieu A, Do H . Human NELL-1 expressed in unilateral coronal synostosis. J Bone Miner Res. 1999; 14(1):80-9. DOI: 10.1359/jbmr.1999.14.1.80. View

Yoshikawa H, Takaoka K, Masuhara K, Ono K, Sakamoto Y . Prognostic significance of bone morphogenetic activity in osteosarcoma tissue. Cancer. 1988; 61(3):569-73. DOI: 10.1002/1097-0142(19880201)61:3<569::aid-cncr2820610324>3.0.co;2-z. View

Vahle J, Sato M, Long G, Young J, Francis P, Engelhardt J . Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol. 2002; 30(3):312-21. DOI: 10.1080/01926230252929882. View

Mori Y, Cai K, Cheng Y, Wang S, Paun B, Hamilton J . A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. Gastroenterology. 2006; 131(3):797-808. DOI: 10.1053/j.gastro.2006.06.006. View

Cusano N, Bilezikian J . Combination anabolic and antiresorptive therapy for osteoporosis. Endocrinol Metab Clin North Am. 2012; 41(3):643-54. DOI: 10.1016/j.ecl.2012.04.005. View

Nguyen A, Scott M, Dry S, James A . Roles of bone morphogenetic protein signaling in osteosarcoma. Int Orthop. 2014; 38(11):2313-22. DOI: 10.1007/s00264-014-2512-x. View

Chen F, Walder B, James A, Soofer D, Soo C, Ting K . NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. Int Orthop. 2012; 36(10):2181-7. PMC: 3460081. DOI: 10.1007/s00264-012-1590-x. View

James A, Shen J, Zhang X, Asatrian G, Goyal R, Kwak J . NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015; 6:7362. PMC: 4557288. DOI: 10.1038/ncomms8362. View

Friedlaender G, Perry C, Cole J, Cook S, Cierny G, Muschler G . Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001; 83-A Suppl 1(Pt 2):S151-8. PMC: 1425155. View

10.

Yuan W, James A, Asatrian G, Shen J, Zara J, Tian H . NELL-1 based demineralized bone graft promotes rat spine fusion as compared to commercially available BMP-2 product. J Orthop Sci. 2013; 18(4):646-57. DOI: 10.1007/s00776-013-0390-5. View

11.

Freire M, You H, Kook J, Choi J, Zadeh H . Antibody-mediated osseous regeneration: a novel strategy for bioengineering bone by immobilized anti-bone morphogenetic protein-2 antibodies. Tissue Eng Part A. 2011; 17(23-24):2911-8. DOI: 10.1089/ten.tea.2010.0584. View

12.

Li W, Lee M, Whang J, Siu R, Zhang X, Liu C . Delivery of lyophilized Nell-1 in a rat spinal fusion model. Tissue Eng Part A. 2010; 16(9):2861-70. PMC: 2928135. DOI: 10.1089/ten.tea.2009.0550. View

13.

Body J, Gaich G, Scheele W, Kulkarni P, Miller P, Peretz A . A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2002; 87(10):4528-35. DOI: 10.1210/jc.2002-020334. View

14.

Sotobori T, Ueda T, Myoui A, Yoshioka K, Nakasaki M, Yoshikawa H . Bone morphogenetic protein-2 promotes the haptotactic migration of murine osteoblastic and osteosarcoma cells by enhancing incorporation of integrin beta1 into lipid rafts. Exp Cell Res. 2006; 312(19):3927-38. DOI: 10.1016/j.yexcr.2006.08.024. View

15.

Zhang X, Zara J, Siu R, Ting K, Soo C . The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. J Dent Res. 2010; 89(9):865-78. PMC: 2959101. DOI: 10.1177/0022034510376401. View

16.

Jin Z, Mori Y, Yang J, Sato F, Ito T, Cheng Y . Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. Oncogene. 2007; 26(43):6332-40. DOI: 10.1038/sj.onc.1210461. View

17.

Gobbi G, Sangiorgi L, Lenzi L, Casadei R, Canaider S, Strippoli P . Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells. Int J Oncol. 2001; 20(1):143-7. View

18.

Aghaloo T, Cowan C, Chou Y, Zhang X, Lee H, Miao S . Nell-1-induced bone regeneration in calvarial defects. Am J Pathol. 2006; 169(3):903-15. PMC: 1698834. DOI: 10.2353/ajpath.2006.051210. View

19.

Yoshikawa H, Takaoka K, Hamada H, Ono K . Clinical significance of bone morphogenetic activity in osteosarcoma. A study of 20 cases. Cancer. 1985; 56(7):1682-7. DOI: 10.1002/1097-0142(19851001)56:7<1682::aid-cncr2820560735>3.0.co;2-8. View

20.

Siu R, Lu S, Li W, Whang J, McNeill G, Zhang X . Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A. 2010; 17(7-8):1123-35. PMC: 3063712. DOI: 10.1089/ten.TEA.2010.0486. View