Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Apr 5

PMID 27042662

Citations 10

Authors

Eike Tigges

Daniel Kalbacher

Christina Thomas

Sebastian Appelbaum

Florian Deuschl

Niklas Schofer

Michael Schluter

Lenard Conradi

Johannes Schirmer

Hendrik Treede

Hermann Reichenspurner

Stefan Blankenberg

Ulrich Schafer

Edith Lubos

Affiliations

Soon will be listed here.

Abstract

Background: Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.

Methods: 592 consecutive patients (75 ± 8.7 years, 362 men, 230 women) underwent clinical and echocardiographic follow-up for a median of 2.13 (0.99-4.02) years.

Results: Significantly higher prevalence of cardiovascular comorbidities, renal failure, and adverse echocardiographic parameters in men resulted in longer device time (p = 0.007) and higher numbers of implanted clips (p = 0.0075), with equal procedural success (p = 1.0). Rehospitalization for heart failure did not differ (p[logrank] = 0.288) while survival was higher in women (p[logrank] = 0.0317). Logarithmic increase of NT-proBNP was a common independent predictor of death. Hypercholesterolemia and peripheral artery disease were predictors of death only in men while ischemic and dilative cardiomyopathy (CM) and age were predictors in women. Independent predictors of rehospitalization for heart failure were severely reduced ejection fraction and success in men while both ischemic and dilative CM, logistic EuroSCORE, and MR severity were predictive in women.

Conclusions: Higher numbers of implanted clips and longer device time are likely related to more comorbidities in men. Procedural success and acute and mid-term clinical outcomes were equal. Superior survival for women in long-term analysis is presumably attributable to a comparatively better preprocedural health.

Citing Articles

Mitral Regurgitation in Female Patients: Sex Differences and Disparities.

Ocher R, May M, Labin J, Shah J, Horwich T, Watson K J Soc Cardiovasc Angiogr Interv. 2024; 2(4):101032.

PMID: 39131652 PMC: 11308238. DOI: 10.1016/j.jscai.2023.101032.

Guideline-endorsed follow-up after percutaneous valve therapies-non-attendance of TAVI and MitraClip patients.

Schmidt F, Geyer M, Sotiriou E, Ardic Y, Sadegh P, Schulz E Herz. 2024; 49(5):371-377.

PMID: 38743296 DOI: 10.1007/s00059-024-05245-2.

Sex-Specific Disparities in Outcomes of Transcatheter Edge-to-Edge Repair for Mitral Regurgitation: A Multicenter "Real-World" Analysis.

Ausbuettel F, Barth S, Chatzis G, Sassani K, Fischer D, Weyand S J Clin Med. 2023; 12(23).

PMID: 38068282 PMC: 10706895. DOI: 10.3390/jcm12237231.

Yi K, Gao J, Wang W, Ma Y, Wang W, He S J Cardiothorac Surg. 2023; 18(1):31.

PMID: 36650548 PMC: 9843892. DOI: 10.1186/s13019-023-02123-6.

Sex-Specific Difference in Outcomes after Transcatheter Mitral Valve Repair with MitraClip Implantation: A Systematic Review and Meta-Analysis.

Sun F, Liu H, Zhang Q, Zhou J, Zhan H, Lu F J Interv Cardiol. 2022; 2022:5488654.

PMID: 35281587 PMC: 8885186. DOI: 10.1155/2022/5488654.

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