Correlation of Endothelial Nitric Oxide Synthase Gene Polymorphism (GG, TT and GT Genotype) with Proteinuria and Retinopathy in Type 2 Diabetic Patients

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2016 Apr 5

PMID 27042499

Citations 6

Authors

Ali Momeni

Morteza Hashemzadeh Chaleshtori

Saeed Saadatmand

Soleiman Kheiri

Affiliations

Soon will be listed here.

Abstract

Background: Nephropathy is the most important leading cause of end stage renal failure in type 2 diabetic patients, so numerous studies were done to diagnose and evaluate risk factors of diabetic nephropathy (DN). Some gene polymorphisms may be associated with progression or regression of DN, so the aim of this study was to compare prevalence of eNOS gene polymorphism in diabetic patients with controls and its association with diabetic nephropathy.

Materials And Methods: In a cross-sectional study, 94 type 2 diabetic patients and 94 normal participants were enrolled. Patients without retinopathy were excluded from this study. For all of the patients, fasting blood sugar (FBS), 2 hours post-prandial (BS), Blood Urea Nitrogen (BUN), Creatinine (Cr), 24 hours urine protein were measured in the case group. Endothelial nitric oxide synthetase gene polymorphism was evaluated in the case and control groups.

Results: There was no significant difference based on age and sex between patients in case and control groups. GG genotype of eNOS was less common in the patient group compared to control group. There was no difference between prevalence of TT, GT or GG genotype based on age and sex. There was no correlation between diabetic retinopathy or proteinuria and genotypes of eNOs.

Conclusion: The study showed that in type 2 diabetic patients, NOS gene polymorphism was more common compared to normal population; however, there is no correlation between this gene polymorphism and proteinuria or retinopathy in these patients.

Citing Articles

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review.

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Evaluation of Association Studies and Meta-Analyses of Polymorphisms in Type 2 Diabetes Mellitus Risk.

Wang D, Liu L, Zhang C, Lu W, Wu F, He X Front Genet. 2022; 13:887415.

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Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World.

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Retinal Physiology and Circulation: Effect of Diabetes.

Wright W, Eshaq R, Lee M, Kaur G, Harris N Compr Physiol. 2020; 10(3):933-974.

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Nitric Oxide Gene Polymorphism is a Risk Factor for Diabetic Nephropathy and Atherosclerosis in Type 1 Diabetic Patients.

Dayem S, Battah A, Bohy A, Ahmed S, Hamed M, Fattah S Open Access Maced J Med Sci. 2020; 7(19):3132-3138.

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