N-(11)C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with (13)N-Ammonia PET

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Apr 2

PMID 27034950

Citations 1

Authors

Weina Zhou

Xiangcheng Wang

Yulin He

Yongzhen Nie

Guojian Zhang

Cheng Wang

Chunmei Wang

Xuemei Wang

Affiliations

Soon will be listed here.

Abstract

Objective: Using a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury.

Methods: Acute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the presence of myocardial ischemia. Paired (11)C-MDA PET and (13)N-ammonia PET scans were performed at baseline, 1 day, and 1, 3, and 6 months after surgery to relate cardiac sympathetic nerve injury to blood perfusion.

Results: Seven survived the surgical procedure. The ECG-ST segment was depressed, and levels of the serum enzymes increased. Cardiac uptake of tracer was quantified as the defect volume. Both before and immediately after surgery, the images obtained with (11)C-MDA and (13)N-ammonia were similar. At 1 to 6 months after surgery, however, (11)C-MDA postsurgical left ventricular myocardial defect volume was significantly greater compared to (13)N-ammonia.

Conclusions: In the Chinese minipig model of acute myocardial ischemia, the extent of the myocardial defect as visualized by (11)C-MDA is much greater than would be suggested by blood perfusion images, and the recovery from myocardial sympathetic nerve injury is much slower than the restoration of blood perfusion. (11)C-MDA PET may provide additional biological information during recovery from ischemic heart disease.

Citing Articles

CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway.

Long T, Jing R, Kuang F, Huang L, Qian Z, Yang T Braz J Med Biol Res. 2017; 50(4):e5861.

PMID: 28355355 PMC: 5423751. DOI: 10.1590/1414-431X20175861.

References

Matsunari I, Schricke U, Bengel F, Haase H, Barthel P, Schmidt G . Extent of cardiac sympathetic neuronal damage is determined by the area of ischemia in patients with acute coronary syndromes. Circulation. 2000; 101(22):2579-85. DOI: 10.1161/01.cir.101.22.2579. View

Cohen-Solal A, Rouzet F, Berdeaux A, Le Guludec D, Abergel E, Syrota A . Effects of carvedilol on myocardial sympathetic innervation in patients with chronic heart failure. J Nucl Med. 2005; 46(11):1796-803. View

Raffel D, Wieland D . Assessment of cardiac sympathetic nerve integrity with positron emission tomography. Nucl Med Biol. 2001; 28(5):541-59. DOI: 10.1016/s0969-8051(01)00210-4. View

Kawai Y, Tsukamoto E, Nozaki Y, Morita K, Sakurai M, Tamaki N . Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain. J Am Coll Cardiol. 2001; 38(7):1888-94. DOI: 10.1016/s0735-1097(01)01634-5. View

Joho S, Asanoi H, Takagawa J, Kameyama T, Hirai T, Nozawa T . Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia. J Am Coll Cardiol. 2002; 39(3):436-42. DOI: 10.1016/s0735-1097(01)01770-3. View

Bonow R, Smaha L, Smith Jr S, Mensah G, Lenfant C . World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic. Circulation. 2002; 106(13):1602-5. DOI: 10.1161/01.cir.0000035036.22612.2b. View

Watanabe K, Takahashi T, Miyajima S, Hirokawa Y, Tanabe N, Kato K . Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina. J Nucl Med. 2002; 43(11):1476-81. View

Bulow H, Stahl F, Lauer B, Nekolla S, Schuler G, Schwaiger M . Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction. Nucl Med Commun. 2003; 24(3):233-9. DOI: 10.1097/00006231-200303000-00002. View

Simoes M, Barthel P, Matsunari I, Nekolla S, Schomig A, Schwaiger M . Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction. Eur Heart J. 2004; 25(7):551-7. DOI: 10.1016/j.ehj.2004.02.016. View

10.

Bengel F, Schwaiger M . Assessment of cardiac sympathetic neuronal function using PET imaging. J Nucl Cardiol. 2004; 11(5):603-16. DOI: 10.1016/j.nuclcard.2004.06.133. View

11.

Wieland D, Brown L, Rogers W, Worthington K, Wu J, Clinthorne N . Myocardial imaging with a radioiodinated norepinephrine storage analog. J Nucl Med. 1981; 22(1):22-31. View

12.

Stanton M, Tuli M, Radtke N, Heger J, Miles W, Mock B . Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine. J Am Coll Cardiol. 1989; 14(6):1519-26. DOI: 10.1016/0735-1097(89)90391-4. View

13.

Schwaiger M, Kalff V, Rosenspire K, Haka M, Molina E, Hutchins G . Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation. 1990; 82(2):457-64. DOI: 10.1161/01.cir.82.2.457. View

14.

McGhie A, Corbett J, Akers M, Kulkarni P, Sills M, Kremers M . Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction. Am J Cardiol. 1991; 67(4):236-42. DOI: 10.1016/0002-9149(91)90552-v. View

15.

Dae M, Herre J, OConnell J, Botvinick E, Newman D, Munoz L . Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. J Am Coll Cardiol. 1991; 17(6):1416-23. DOI: 10.1016/s0735-1097(10)80156-1. View

16.

Packer M . The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol. 1992; 20(1):248-54. DOI: 10.1016/0735-1097(92)90167-l. View

17.

Ewing D . Diabetic autonomic neuropathy and the heart. Diabetes Res Clin Pract. 1996; 30 Suppl:31-6. DOI: 10.1016/s0168-8227(96)80036-2. View

18.

Sakata K, Shirotani M, Yoshida H, Kurata C . Iodine-123 metaiodobenzylguanidine cardiac imaging to identify and localize vasospastic angina without significant coronary artery narrowing. J Am Coll Cardiol. 1997; 30(2):370-6. DOI: 10.1016/s0735-1097(97)00159-9. View

19.

Hartikainen J, Mustonen J, Kuikka J, Vanninen E, Kettunen R . Cardiac sympathetic denervation in patients with coronary artery disease without previous myocardial infarction. Am J Cardiol. 1997; 80(3):273-7. DOI: 10.1016/s0002-9149(97)00345-7. View

20.

INOBE Y, Kugiyama K, Miyagi H, Ohgushi M, Tomiguchi S, Takahashi M . Long-lasting abnormalities in cardiac sympathetic nervous system in patients with coronary spastic angina: quantitative analysis with iodine 123 metaiodobenzylguanidine myocardial scintigraphy. Am Heart J. 1997; 134(1):112-8. DOI: 10.1016/s0002-8703(97)70114-5. View